This study is concerned with the mechanism of exchange of sodium between plasma and cerebrospinal fluid (CSF). Several workers (1, 2) have reported that there is no significant difference between the concentration of sodium in plasma and CSF. Merritt and Fremont-Smith (3) reported that the average concentration of sodium in CSF, in man, exceeded the plasma concentration by about four mEq. Davso...

1. Balance studies have been made on three dogs before and after adrenalectomy, performed in two stages. 2. It has been shown that the sodium concentration of the blood decreases in adrenalectomized dogs, as is true in patients suffering from Addison's disease and in cats experimentally adrenalectomized. 3. There are also decreases in the chloride and bicarbonate concentrations which together a...

BACKGROUND Hyponatremia is a common electrolyte abnormality among patients hospitalized with heart failure and it is a marker for increased short-term and long-term mortality. However, little is known about the time course of hyponatremia and whether changes in serum sodium levels affect clinical outcomes. METHODS AND RESULTS Patients (n=322) hospitalized with decompensated heart failure and ...

Experiments are described which indicate that iodinated human serum albumin underestimates the amount of extracellular sodium trapped in the packed layer of red blood cells, when cells and plasma are separated by centrifugation. Sucrose-(14)C also underestimates the amount of trapped extracellular sodium, but the difference between the percentages of sucrose-(14)C and extracellular sodium trapp...

Sodium and potassium influxes and outfluxes have been studied in single isolated muscle fibers from the giant barnacle both by microinjection and by external loading. The sodium influxes and outfluxes were 49 and 39 pmoles /cm(2)-sec (temperature = 15-16 degrees C) respectively. The potassium influxes and outfluxes were 28 and 60 pmoles/cm(2)-sec (temperature = 13-16 degrees C) respectively. Re...

AIM The change of antemortem blood alcohol concentration (BAC) in inadequately processed samples was examined. METHODS The study was performed on nine healthy, sober volunteers after overnight fasting. Blood samples were divided into groups and stored, with or without NaF, for varying time periods (12, 24 and 48 h) and at different temperatures (4 degrees C and 20 degrees C). BAC analysis was...

The development of contracture related to changes of ionic environment (ionic contracture coupling) has been studied in the slowly responding fibers of frog skeletal muscle. When deprived of external ions for 30 minutes by use of solutions of sucrose, mannitol, or glucose, the slow skeletal muscle fibers, but not the fast, develop pronounced and easily reversible contractures. Partial replaceme...

Noninvasive methods of detecting cartilage degeneration can have an impact on identifying the early stages of osteoarthritis. Accurate measurement of sodium concentrations within the cartilage matrix provides a means for analyzing tissue integrity. Here a method is described for quantitating sodium concentration and visibility in cartilage, with general applications to all tissue types. The sod...

The following measurements were made in normal children, children with primary hypertension, and children with secondary hypertension: erythrocyte intracellular sodium concentration, total sodium efflux rate constant, and maximum binding of ouabain to erythrocytes reflecting the number of sodium/potassium adenosine triphosphatase pump sites. Children with primary hypertension had a significantl...