In this study, we investigated the mechanism that links activation of N-methyl-D-aspartate (NMDA) receptors to inhibition of voltage-gated sodium channels in isolated catfish cone horizontal cells. NMDA channels were activated in voltage-clamped cells incubated in low-calcium saline or dialyzed with the calcium chelator BAPTA to determine that calcium influx through NMDA channels is required fo...

Calcium- and sodium- activated potassium channels are members of the 6TM family K which comprises voltage-gated KV subfamilies, including KCNQ subfamily, EAG subfamily (which includes hERG channels), Ca2+-activated Slo (actually with 6 or 7TM) Ca2+- Na+-activated SK (nomenclature as agreed by NC-IUPHAR Subcommittee on sodium-activated [126]). As for 2TM family, pore-forming a subunits form tetr...