Objective(s): Study and development of antifouling nanosystem for conjugation of drugs were attracting great attention in recent years. The present study aimed to develop novel curcumin-loaded silica nanoparticles containing zwitterionic coating as an antifouling system to provide protein corona free nanoformulations for curcumin. Materials and Methods: Silica nanoparticles were prepared ...

Objective: This study was employed to evaluate the quality of marketed oral tablets containing clopidogrel bisulfate. Tablets produced by various companies and commercialized in Iraq market were used study. Methods: Batches bisulfate conventional (containing 75 mg drug) exposed control tests. These tests involved friability, weight variation, hardness, drug content, disintegration time, vitro r...

We reported previously that freshly fractured silica (FFSi) induces activator protein-1 (AP-1) activation through extracellular signal-regulated protein kinases (ERKs) and p38 kinase pathways. In the present study, the biologic activities of FFSi and aged silica (ASi) were compared by measuring their effects on the AP-1 activation and phosphorylation of ERKs and p38 kinase. The roles of reactiv...

Open sun drying of horticultural produce results in contamination due to microbial and fungal attacks could also be damaged by insects, pests, rodents. Solar through solar collectors is, therefore, an important technique used for the preservation foods extend shelf life produce, thereby reducing attack contamination. Therefore, experiment was carried out study response kinetics solar-dried toma...

Epidermal growth factor (EGF) is an important factor for healing after tissue damage in diverse experimental models. It plays an important role in liver regeneration (LR). The objective of this experiment is to investigate the methylation variation of 10 CpG sites in the Egf promoter region and their relevance to Egf expression during rat liver regenera- tion. As a follow up of our previous stu...

Abstract Although the initial in vitro dissolution of bioactive glasses (BAG) is well characterized, long-term behaviour crystallized BAG scaffolds a continuous fluid flow incompletely understood. A detailed understanding vital for predicting their clinical applications. Here, we explored and reaction mechanisms partly crystalline glass–ceramic based on S53P4 45S5 using flow-through method Tris...

The most commonly used protocol of the RNA isolation, the guanidine thiocyanate method, was unsuitable for recalcitrant plant tissues containing a large amount of storage proteins and secondary metabolites. We demonstrated that RNA could bind to the silica particles, which have been used successfully in DNA isolation from various sources, under a high concentration of NaCl in the presence of et...

Large colloidal environmentally stable silica-coated cobalt particles were synthesized by combining the sodium borohydride reduction in aqueous solution and the Stöber method. Low size polydisperse cobalt spheres with an average size of 95 nm were synthesized by using a borohydride reduction method and were subsequently coated with a thin layer of silica by means of hydrolysis and condensation ...