This study first reports the pharmacokinetic disposition of polyethylene glycol (PEG)-modified salmon calcitonin (sCT) based on the number of attached PEG molecules. PEG-modified sCT was prepared by covalent linkage with succinimidyl carbonate monomethoxy polyethylene glycol. Mono- and di-PEG-sCTs were separated by size exclusion and reverse phase HPLC, and radioiodinated by the chloramine-T me...

BACKGROUND This study examines sickle cell trait (SCT) as a cause of sudden death in National Collegiate Athletic Association (NCAA) athletes and explores the cost-effectiveness of different screening models. METHODS The authors reviewed the cause of all cases of sudden death in NCAA student-athletes from January 2004 through December 2008. The authors also explored the cost-effectiveness of ...

Patients undergoing allogeneic stem cell transplantation (allo-SCT) with reduced intensity conditioning (RIC) for multiple myeloma (MM) experience a high frequency of extra-medullary relapses (EMR) (20–37%). This study aims at determining factors predictive for EMR after allo-SCT, prognosis of EMR and efficacy of salvage therapies. We retrospectively analyzed a continuous cohort of 79 patients ...

Allogeneic stem cell transplantation (allo-SCT) is a potential cure for patients with malignant lymphoma that is based on the graft-versus-lymphoma (GVL) effect. Myeloablative conditioning allo-SCT is associated with high mortality and morbidity, particularly in patients older than 45 years, heavily pretreated patients (prior hematopoietic stem cell transplantation or more than two lines of con...

Survival of pediatric acute myeloid leukemia (AML) has improved considerably over the past decades. Since 1985, allogeneic stem cell transplantation (allo-SCT) is widely recommended for patients who have a matched sibling donor. However, it remains controversial whether allo-SCT is superior to chemotherapy for children with newly diagnosed AML. This review summarizes phase 3 clinical trials tha...

Our aim in this article is to argue that an adequate account of semantic development in early ®rst language acquisition requires a theory and methodology that synthesize the insights of cognitive and cultural linguistics with a Vygotskian sociocultural approach to human development. This involves recasting and extending the notion of embodiment, which is a central philosophical underpinning of ...

OBJECTIVE The purpose of the present study was to assess sluggish cognitive tempo (SCT) behavioral symptoms among pediatric survivors of acute lymphoblastic leukemia (ALL) and to determine the relationship of these behaviors with cognitive late effects. METHODS ALL survivors (n = 80) and a sibling control group (n = 19) were administered intelligence (IQ) testing, achievement testing and SCT ...

Social cognitive optimization (SCO) for solving nonlinear programming problems (NLP) is presented based on human intelligence with the social cognitive theory (SCT). The experiments by comparing SCO with genetic algorithms on some benchmark functions show that it can get highquality solutions efficiently, even by only one learning agent.

Clinical research published since the 2001 evidence-based review on the role of hematopoietic stem cell transplantation (SCT) in the treatment of diffuse large B cell lymphoma (DLBCL) in adults is presented and critically evaluated in this update. Treatment recommendations that remain unchanged from the original review include: (1) autologous SCT as salvage therapy is recommended for patients w...