Crotalus durissus cumanensis snake venoms from different Venezuelan regions, showed biochemical and hemostatic variations. Fibrino(geno)lytic, hemorrhagic and procoagulant activities and gel-filtration chromatography and SDS-PAGE profiles were analyzed. Differences were observed in fibrinolytic activity: kallikrein-like amidolytic activity was highest in venoms of Santa Teresa, and Margarita. L...

Snake venoms are important sources of complex substances with a variety pharmacological activities. Among them serine proteinases (SVSPs) have effects on the hemostatic system influencing hemodynamic human or animal blood. Bothrops genus-snake rich in thrombin-like enzyme, type SVSPs, great interest to produce medicine. Therefore, aim this work was describe rapid, only two-step chromatographic-...

The review is mainly devoted to snake venom a-neurotoxins which target different muscle-type and neuronal nicotinic acetylcholine receptors. The primary and spatial structures of other snake venom proteins as well as mammalian proteins of the Ly-6 family, which structurally resemble the `three-finger' snake proteins, are also briefly discussed. The main emphasis is placed on recent data charact...

BACKGROUND AND OBJECTIVES We evaluated a new test, based on prothrombin activation by Echis Carinatus snake venom in the absence/presence of unfractionated heparin, in patients with venous thromboembolism (VTE). DESIGN AND METHODS The test (activated prothrombin heparin-inhibition test) was performed in 555 unselected, unrelated patients who had suffered from at least one objectively confirme...

Bridging systems biology and pharmacokinetics-pharmacodynamics has resulted in models that are highly complex and complicated. They usually contain large numbers of states and parameters and describe multiple input-output relationships. Based on any given data set relating to a specific input-output process, it is possible that some states of the system are either less important or have no infl...

BACKGROUND Snakebite is a major public health problem in many developing countries. Farmers are particularly exposed to snakes, and due to their rural location often experience delays in accessing formal healthcare. The reasons to use traditional healers may include difficulties in accessing formal healthcare, certain beliefs about snakes and snake venom, tradition, and trust in the capacity of...

Baruipur is one of the five subdivisions of district South 24 Parganas, West Bengal, India. The subdivision is again comprised of seven blocks. People residing in these blocks are severely affected by the incidence of snakebite. Hundreds of people die of snake venom each year in this district. A survey was conducted in the seven blocks of the subdivision in search of potential anti ophidian bot...

OBJECTIVE To look into the feasibility of using cobra snake venom in suppressing breast cancer tissue through inhibition of nucleic acid synthesis. METHODS Samples of breast cancerous tissue, obtained from Atomic Energy Medical Center, LMCH, Jamshoro, incubated with varying concentrations of venom and without venom (as controls) were assayed for macromolecular (RNA and DNA) levels RESULTS N...

OBJECTIVE To demonstrate that use of lower doses of anti-snake venom is as effective as high doses and is associated with less complications and lower mortality especially in the wake of rising cost of medical treatment, the people most affected by snakebites being the poor farmers. METHODOLOGY A prospective descriptive study consisting of 54 snakebite patients fulfilling the inclusion criter...