BACKGROUND Extended field radiotherapy is a standard of care for low volume stage II testicular seminoma. We hypothesized that neoadjuvant carboplatin might reduce the recurrence risk. PATIENTS AND METHODS In a single-arm study, 51 patients were treated between May 1996 and November 2011 with a single cycle of carboplatin followed by radiotherapy. The radiation field was reduced from an exten...

OBJECTIVE Cardiac irradiation during left-sided breast radiotherapy may lead to deleterious cardiac side effects. Using image guided radiotherapy, it is possible to exclude the heart from treatment fields and monitor reproducibility of virtual simulation (VS) fields at treatment delivery using electronic portal imaging (EPI). Retrospectively, we evaluate the incidence of cardiac irradiation at ...

Cancer medicine is slowly embracing the uncomfortable reality that adjuvant modalities are often best administered before operative surgery rather than after. Cedermark points out that there are 20 published series which show a clear survival advantage for pre-operative radiotherapy in rectal cancer and only one showing such advantage for post-operative radiotherapy. Similarly direct comparison...

--3-dimensional breast radiotherapy is the most prevalent techniques, carried out in all radiotherapy centers of the world including Iran. The objective of this study is to investigate the dose rate supplied to the opposite breast during the radiotherapy of breast cancer using the designing method of 3-dimensional therapy. 32 female patients suffering from breast cancer participated in this stu...

BACKGROUND Cutaneous vascular proliferations that occur in the field of prior radiotherapy include angiosarcoma and small, cutaneous lesions with a pseudosarcomatous pattern that previously were reported as atypical vascular lesions or benign lymphangiomatous papules. METHODS The objective of this study was to investigate the clinicopathologic features and outcomes of 56 radiation-induced vas...

BACKGROUND In the treatment of prostate carcinoma, radiotherapy and surgery are common choices of comparable efficacy; thus a realistic comparison of the potential long term sequelae, such as the risk of second malignancy, may be of relevance to treatment choice. METHODS Data regarding the rate of incidence from the Surveillance, Epidemiology, and End Results Program cancer registry (1973-199...

For patients with locally unresectable recurrent nasopharyngeal carcinoma who relapsed after 2 years of radiotherapy, re-radiotherapy is also the preferred treatment. However, for within years, use would be greatly limited by its adverse effects. Consequently, finding a new strategy to prolong time very necessary reduce related side effects and improve curative effect. Anlotinib an orally avail...

Background: Human beta-defensins (hBDs) are small cationic peptides of the epithelium with broad antimicrobial and immune response-regulatory activities. hBDs also related to oncogenesis, their secretion profiles affected by radiotherapy treatment. The present study aimed investigate oral cavity hBD 1-3 levels in head neck cancer patients its relation Methods: Sixteen (all a history smoking) we...

Introduction: Rectal and bladder cancer are the most common disease among young man. Although External Radiotherapy (EBRT) is one of the most effective treatment options introduced so far, the testis undesired radiation dose increases the risk of infertility and hormonal malfunctioning. The testicles are usually outside of the radiation field, but they can be exposed either to ...