BACKGROUND Many studies suggest that long term potentiation (LTP) has a role in learning and memory. In contrast, little is known about the function of short-lived plasticity (SLP). Modeling results suggested that SLP could be responsible for temporary memory storage, as in working memory, or that it may be involved in processing information regarding the timing of events. These models predict ...

[1] The annual and interannual variations of sea level pressure (SLP) over the Southern Ocean are investigated using the NCEP/NCAR reanalysis data from 1968 to 2005. Results show that the weakening of the Semiannual Oscillation (SAO) has continued to present day but does not occur homogeneously across all longitudes. While the second harmonic of SLP has decreased over the South Pacific Ocean, i...

p95vav, the product of the vav protooncogene, has been implicated in the T cell receptor (TCR)-mediated signaling cascade p95vav is phosphorylated on tyrosine residues after TCR stimulation by anti-TCR/CD3 antibodies and possesses a number of landmark features of signaling molecules such as a putative guanine nucleotide exchange factor domain, a pleckstrin homology domain, and an Sre homology (...

The 30-year normalized-difference vegetation index (NDVI) time series from AVHRR/MODIS satellite sensors was used in this study to assess the regional vegetation dynamic changes in the Tao River Basin, which cuts across the Eastern Tibetan Plateau (ETP) and the Southwestern Loess Plateau (SLP). First, principal component and correlation analyses were carried out to determine the key climatic va...

To probe genetic variation in the regulation of sexual dimorphism, we have characterized the mouse protein Slp, coded by the gene sex-limited protein (Slp). Slp expression in many strains is limited to males and is androgen-dependent. However, female expression is also observed in rare strains, due to nonlinked gene(s) termed regulator of sex-limitation (rsl). In this report we demonstrate that...

Episodes of choking during medication administration to patients with dysphagia prompted a chart audit and caregiver interview to identify system problems that allowed inappropriate drug administration to occur. Sixty elderly patients residing on two patient care areas in a 500-bed complex continuing care facility were studied. The audit explored the actual nursing medication administration met...

The neural circuitry and biomechanics of kicking in locusts have been studied to understand their roles in the control of both kicking and jumping. It has been hypothesized that the same neural circuit and biomechanics governed both behaviors but this hypothesis was not testable with current technology. We built a neuromechanical model to test this and to gain a better understanding of the role...

Although adaptor ADAP (FYB) and its binding to SLP-76 has been implicated in TcR-induced "inside-out" signaling for LFA-1 activation in T cells, little is known regarding its role in LFA-1-mediated "outside-in" signaling. In this study, we demonstrate that ADAP and SLP-76-ADAP binding are coupled to LFA-1 costimulation of IL-2 production, F-actin clustering, cell polarization, and T cell motili...

The traditional view of how intracellular effector proteins are recruited to the B cell antigen receptor (BCR) complex at the plasma membrane is based on the occurrence of direct protein-protein interactions, as exemplified by the recruitment of the tyrosine kinase Syk (spleen tyrosine kinase) to phosphorylated motifs in BCR signaling subunits. By contrast, the subcellular targeting of the cyto...

The Serious Leisure Perspective (SLP) divides leisure activity into three forms: serious, casual and project-based, each with a number of distinguishing qualities, rewards, costs benefits. It is presented by its creator, Robert Stebbins, as both classification system theoretical framework. In early history, it was seen micro-level, or at most meso-level, construct concerned the behaviour indivi...