background and purpose: ischemic heart diseases (ihd) is getting as the most common and the main causes of heart diseases and mortalities worldwide affecting the quality of life (qol) of the patients. this study was conducted to determine the qol for the patients with ihd referring to medical centers of kashan in 2007. methods: this cross-sectional study was performed on all patients (n =500) r...

Melatonin is a physiological hormone involved in sleep timing and is currently used exogenously in the treatment of primary and secondary sleep disorders with empirical evidence of efficacy, but very little evidence from randomised, controlled studies. The aim of this meta-analysis was to assess the evidence base for the therapeutic effects of exogenous melatonin in treating primary sleep disor...

Obstructive sleep apnea is recognized as having high prevalence and causing remarkable cardiovascular risk. Coronary artery disease has been associated with obstructive sleep apnea in many reports. The pathophysiology of coronary artery disease in obstructive sleep apnea patients probably includes the activation of multiple mechanisms, as the sympathetic activity, endothelial dysfunction, ather...

Introduction: Postoperative wound infection is a complication that occurs after coronary artery bypass graft surgery. The aim of this study was to examine the incidence of wound infections after coronary artery bypass graft surgery among the patients operated in Ghaem Hospital in the city of Mashhad from 2009-2011. Methods: This cross-sectional study was performed in the years 2009 to 2011 o...

Post cardiac surgery patients require intensive monitoring, judicious use of cardiovascular drugs, effective pain control, early mobilization, and intense respiratory care. In the last decade, off-pump coronary artery bypass surgery (OPCAB) that avoids the use of cardiopulmonary bypass (CPB) and aortic cannulation has evolved. With the advent of new instruments, multi vessel bypass is now perfo...

Circadian rhythm sleep-wake disorders (CRSWDs) are characterized by persistent or recurrent patterns of sleep disturbance related primarily to alterations of the circadian rhythm system or the misalignment between the endogenous circadian rhythm and exogenous factors that affect the timing or duration of sleep. These disorders collectively represent a significant unmet medical need, with a tota...

BACKGROUND The effect of sleep apnea on mortality and cardiovascular morbidity is mainly unknown. We aimed to study whether sleep apnea is related to stroke, death, or myocardial infarction in patients with symptomatic coronary artery disease. METHODS AND RESULTS A total of 392 men and women with coronary artery disease referred for coronary angiography were examined by use of overnight sleep...

During and after coronary artery bypass grafting (CABG), oxidative stress occurs. Finding an effective way to improve antioxidant response is important in CABG surgery. It has been shown that patients with coronary heart disease have a low Melatonin production rate. The present study aimed to investigate the effects of Melatoninon nuclear erythroid 2-related factor 2(Nrf2) activity in patients ...