Ubiquitin specific protease 4 (USP4) is a highly networked deubiquitinating enzyme with reported roles in cancer, innate immunity and RNA splicing. In mammals it has two dominant isoforms arising from inclusion or skipping of exon 7 (E7). We evaluated two plausible mechanisms for the generation of these isoforms: (A) E7 skipping due to a long upstream intron and (B) E7 skipping due to inefficie...

Bone mineral accrual during puberty is important, especially in girls, because it is related to reduced risks of osteoporosis in adulthood. Previous research has shown that jumping or plyometric exercises may be effective in increasing bone mineral density in adolescents. Rope skipping is a form of activity that involves jumping, thus regular skipping may also increase bone mineral density in p...

It is well known that one can skip a stone across the water surface, but less well known that a ball can also be skipped on water. The Waboba R © is an elastic ball used in a game of aquatic keep away in which players pass the ball by skipping it along the water. We investigate the physics of skipping elastic balls to elucidate the mechanisms by which they bounce off water. High speed video rev...

Duchenne muscular dystrophy (DMD), the most common muscle degenerative disease, is an X-linked genetic disorder caused by loss or reduction of dystrophin protein, resulting in progressive wasting, and involving skeletal, cardiac, respiratory muscles. There currently no cure for DMD, anti-inflammatory steroid conventional treatment to delay disease progression. Recently, several therapeutic appr...

Police work is mentally demanding and stressful, which takes a heavy toll on the health of police personnel. This study was conducted to assess eating pattern, physical activity nutritional status personnel in Tamale Metropolis. A cross-sectional research design adopted for study. The population this involved all 1590 with two years working experience within Metropolis Northern Region Ghana. Si...

The World Fact Book ranked Cameroon at the 20th position with a fertility rate of 4.66 in 2020. UNSD Database (2020) gives as 5.4, 5.2 and 5.0 for 2005, 2010 2019 respectively. In rank most obese countries, was 135th an average BMI 11.4 2016. 2019, 11.4% Cameroonians were 24.4%. These figures show that years higher rates had lower levels life expectancy BMI. This is possib...