نتایج جستجو برای: skin tumor
تعداد نتایج: 608087 فیلتر نتایج به سال:
Phorbol, the terpene alcohol found in the skin tumor-promoting components of croton oil, was isolated, and four diesters were synthesized from it. The tumor-promoting potencies of these compounds were tested in Charles River GDI mice and skin tumor-susceptible mice. The esters of high tumor-promoting ability (12-O-tetradecanoyl-phorbol-13acetate and phorbol-12,13-didecanoate) were effective in ...
Neurofibromatosis 1 (NF1) is one of the most common genodermatoses and cutaneous neurofibromas (cNFs) manifest in almost every adult with NF1. The immune microenvironment cNFs incompletely known. A total 60 from ten patients NF1 were used for immunolabeling. Tumor T-cells visualized counted based on positive reaction CD3, CD4, CD8 FoxP3. CD68 CD163 to detect macrophages. aggregation cells at tu...
BACKGROUND Transplantation with allogeneic cells has become a promising modality for cancer therapy, which can induce graft-versus-tumor (GVT) effect. This study was aimed at assessing the safety, efficacy, and tissue type GVT (tGVT) response of transplantation with allogeneic skin tumors to treat chemically-induced skin tumors in mice. MATERIAL AND METHODS FVB/N and ICR mice were exposed topic...
Synchronous malignant phyllodes tumor with skin ulceration and invasive carcinoma as collision tumor
Skin tumors are tumors arising from keratinocyte and from adnexal structures. Immunohistochemistry is very helpful in diagnosis of difficult cases in epithelial skin neoplasms, especially basal cell carcinoma (BCC) which is positive for BerEP4, a keratin marker, and mostly negative for epithelial membrane antigen (EMA). Squamous cell carcinoma cells are positive for EMA and cytokeratin, which a...
Multiple molecular mechanisms are involved in the promotion of skin carcinogenesis. Induction of sustained proliferation and epidermal hyperplasia by direct activation of mitotic signaling pathways or indirectly in response to chronic wounding and/or inflammation, or due to a block in terminal differentiation or resistance to apoptosis is necessary to allow clonal expansion of initiated cells w...
Background: Non-melanoma skin cancer is the most common malignant tumor in humans. The role of ultraviolet radiation is well-known in the pathogenesis of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). CD10 is a zinc-dependent metallopeptidase known as common acute lymphoblastic leukemia antigen (CALLA). Although CD10 expression has been investigated in some cutaneous tu...
BACKGROUND Non-melanocytic skin tumors are rarely seen in pediatric patients; although they are mostly benign, they remain to be elucidated by histopathological examination. The objective of the study was to describe the epidemiology of non-melanocytic skin tumors in children attending to our dermatology department. METHOD The histopathologic studies of all skin punch and excisional biopsies ...
In the present study, the ability of metformin to inhibit skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA) was analyzed in mice maintained on either an overweight control diet or an obesity-inducing diet. Rapamycin was included for comparison, and a combination of metformin and rapamycin was also evaluated. Metformin (given in the drinking water) and rapamycin (given topically...
Introduction: Skin cancer has been increased day by day, but it can be cured if it diagnosed early. After reviewing the scientific literature about 980 nm diode laser, and its multiple advantages on skin diseases. We studied in this paper the effectiveness of this type of laser on the progression of skin cancer among hamsters which were exposed to carcinogen on the bac...
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