A hydrogel was prepared by crosslinking aqueous solutions of sulfonated polyacrylamide/chromium triacetate for use in water shut off operations. Gel swelling and the effects of salinity, injection time and flow rate on residual resistance factor (Frr) were investigated. In the presence of electrolytes, gel swelling decreased by about 80%. Results showed that oil permeability increased as inject...

Penetration enhancers are a classical means for improving transdermal drug delivery (TDD). Enhancers permeate into the skin and reversibly decrease the barrier resistance. Basically, our aim is to formulate a transdermal gel containing an appropriate enhancer for a controlled drug release. Terpenes, namely limonene, linalool and cineole, in propylene glycol (PG) were first investigated in vitro...

The aim of this study was to develop suitable microemulsion gel systems for transdermal delivery that could assist dissolution enhancement of poorly water soluble celecoxib and thus improve its skin permeability. Long term oral administration of celecoxib causes serious gastrointestinal adverse effects, which makes it a good candidate for transdermal formulations, yet its low water solubility (...

OBJECTIVE To characterize the epidermal permeability barrier function of skin during exposure to ionizing radiation. DESIGN A prospective cohort study. SETTING University hospital medical center. PATIENTS Fifteen women receiving local radiation therapy (5000-6000 rad [50-60 Gy]) following breast-conserving surgery for breast cancer. MAIN OUTCOME MEASURES Clinical symptoms and transepide...

The topical delivery of non-steroidal anti-inflammatory drugs (NSAIDS) such as Ibuprofen has been explored as a potential method of avoiding the first pass effects and the gastric irritation, which may occur when used orally. Ibuprofen is formulated into many topical preparations to reduce the adverse effects and simultaneously avoid the hepatic first-pass metabolism as well. However, it is dif...

in this paper, the effect of flow rate on relative permeability curves was investigated in iranian carbonate rocks. core samples were prepared from outcrop of asmari formation. the dynamic displacement experiments were performed at 2.55, 3.55, 4.55 and 5.55 cc/hr during waterflooding and oilflooding. relative permeabilities have been calculated with the jones and roszelle method and then the fl...

Quantitative studies show a striking agreement between frog skin and plant tissues in respect to certain important aspects of permeability, antagonism, injury, recovery, and death.

BACKGROUND Celecoxib is a selective cyclo-oxygenase-2 inhibitor recommended orally to treat arthritis and osteoarthritis. It is a highly lipophilic, poorly soluble drug with oral bioavailability of around 40%. Long term oral administration of celecoxib causes serious gastrointestinal side effects. OBJECTIVES The current study aimed to assess the skin permeation of celecoxib by a transdermally...

OBJECTIVE S Transdermal preparations for testosterone are becoming popular because of their unique advantages such as avoidance of first-pass effect, convenience, improved bioavailability, and reduction of systemic side effects. A novel testosterone transdermal delivery system (TDDS) was developed using a palm oil base called HAMIN™ (a commercial product) and tested using in vitro and in vivo s...

It is difficult to accurately measure the volume of transdermally extracted interstitial fluid (ISF), which is important for improving blood glucose prediction accuracy. Skin resistance, which is a good indicator of skin permeability, can be used to determine the volume of extracted ISF. However, it is a challenge to realize in vivo longitudinal skin resistance measurements of microareas. In th...