INTRODUCTION Anal fissure is an ischemic ulcer caused by combination of spasm of internal anal sphincter and poor blood supply to the posterior midline of anal canal. This study aimed to assess the efficacy of Glyceryl Trinitrate and Nifedipine in the treatment of chronic anal fissure. METHODS Ninety patients with symptomatic anal fissure in Kathmandu Medical College Teaching Hospital are all...

Purpose Mutations in the CYP1B1 gene are the most commonly identified genetic causes of primary infantile-onset glaucoma. Despite this disease association, the role of CYP1B1 in eye development and its in vivo substrate remain unknown. In the present study, we used zebrafish to elucidate the mechanism by which cyp1b1 regulates eye development. Methods Zebrafish eye and neural crest developmen...

OBJECTIVES To compare cortical maturation between fetuses with isolated mild ventriculomegaly (IMV) and healthy fetuses, and to explore its potential prognostic value in IMV. METHODS This prospective study quantified cortical maturation by ultrasound in 24 fetuses with IMV and 46 healthy fetuses. Depth and grading the developmental pattern of the parieto-occipital fissure (POF), calcarine fis...

BACKGROUND Chronic anal fissure is one of the most frequent proctological disorders in Western populations. Open lateral internal sphincterotomy is one of the therapeutic options accepted as the treatment of choice for chronic anal fissure, since it reduces the hypertonia of the internal anal sphincter (the main etiopathogenic mechanism of fissures), decreases anal pain, and allows the fissure ...

Stearoyl-CoA desaturase (SCD) is a microsomal rate-limiting enzyme in the cellular synthesis of monounsaturated fatty acids (MUFA), mainly oleate (18:1) and palmitoleate (16:1), which are the major MUFA of membrane phospholipids, cholesterol esters and triglycerides. Three well-characterized isoforms of SCD, SCD1, SCD2 and SCD3, exist in mice. To investigate the physiologic functions of SCD1, w...

STATEMENT OF THE PROBLEM Fissure sealant therapy is among the most effective methods of preventing dental caries. However, it is lengthy and isolation of the teeth is difficult in this procedure especially in young children. Using new hydrophilic fissure sealant may reduce such problems. PURPOSE This study aimed to evaluate the clinical success of a hydrophilic fissure sealant on the lower pe...

The first direct evidence that patterns of basaltic eruptive activity may be very similar on Io and Earth was seen on 26 November 1999, when the Solid State Imaging System on board the Galileo spacecraft obtained high-resolution images of a fissure eruption taking place in one of the calderas of the Tvashtar Catena complex. We analyzed the dynamics of the fissure eruption from the morphology of...

Objective: Radio-opacity is a fundamental requirement for fissure sealants in order to be clearly visible radiographicallyand may be well differentiated from caries. Many attempts have been made to make resin based fissure sealants radio-opaque. Researchers achieved radio-opacity of the sealants by blending heavy metals as fillers into the polymeric matrix. Keeping the demerits of using heavy m...