Microarrays have been proven to be beneficial for understanding the genetics of disease. They are used assess many different types cancers. Machine learning algorithms, like artificial neural network (ANN), can trained determine whether a microarray sample is cancerous or not. The classification performed using features DNA data, which composed thousands gene values. However, most values uninfo...

(+)-SKF 10047 (N-allyl-normetazocine) is a prototypic and specific sigma-1 receptor agonist that has been used extensively to study the function of sigma-1 receptors. (+)-SKF 10047 inhibits K(+), Na(+) and Ca2+ channels via sigma-1 receptor activation. We found that (+)-SKF 10047 inhibited Na(V)1.2 and Na(V)1.4 channels independently of sigma-1 receptor activation. (+)-SKF 10047 equally inhibit...

Previous studies suggest that D1 receptor partial agonists may be viable candidates for development as pharmacotherapies for cocaine addiction. This study investigated the ability of the D1 receptor partial agonists SKF 83959 and SKF 77434 to modulate the behavioral effects of cocaine and compared these effects with those of the reference D1 receptor antagonist SCH 39166 and D1 receptor agonist...

The mechanical properties of the CsH2PO4 and hybrid compounds with different polymers (SKF-26, UPTFE, Butvar B-98) was determined by Vickers microhardness test for first time. It shown that increase in volume fraction polymer results low HV values corresponding to high robustness membranes plastic deformation. Mechanical depend on type best were obtained SKF-26. improvement makes investigated c...

We have performed experiments with SKF 82526, a selective dopamine (DA1) receptor agonist to determine whether this compound would activate either ganglionic and/or central DA receptors. Bilateral hindlimb perfusion was carried out at controlled flow rates and changes in hindlimb perfusion pressure were recorded to evaluate the action of SKF 82526 on vascular resistance in anesthetized dogs. In...

Multiple stressors are intertwined with work, school and living conditions. Finding reasonable strategy to cope up with stresses has become an important issue to the current society. Although an inspiring idea, first proposed by Cassel, suggested that the positive social support could alleviate adverse stress responses, the underlying mechanisms are still uncovered. In the present study, we eva...

Multiple stressors are intertwined with work, school and living conditions. Finding reasonable strategy to cope up with stresses has become an important issue to the current society. Although an inspiring idea, first proposed by Cassel, suggested that the positive social support could alleviate adverse stress responses, the underlying mechanisms are still uncovered. In the present study, we eva...

Although dopaminergic mechanisms are known to modulate cognitive function and cholinergic transmission, their pharmacological characterization remains incomplete. Herein, the role of D1 sites was evaluated employing neurochemical and behavioural approaches. By analogy to the acetylcholinesterase inhibitor, galantamine (0.0025-0.63 mg/kg s.c.), the selective and high efficacy D1 receptor agonist...

In the present study, interactions of dopamine receptor agonists and antagonists with water swimming stress (WSS) on naloxone-induced jumping in morphine-dependent mice were examined. Mice were rendered dependent as described in the methods section. The opioid receptor antagonist, naloxone (1 mg/kg), was injected to elicit jumping (as a withdrawal sign). The first group exposed to WSS in the pr...

1 RIAMTERENE MEDICAL JOURNAL azotaemia with intermittent use of SKF 8542 suggests there is some reversible effect on renal blood-flow. The diuretic response to the combination of SKF 8542 and chlorothiazide is excellent and all patients lost their ascites. The drug was active within a few hours of administration, and, unlike spironolactone, need not be given on consecutive days to obtain a diur...