Trastuzumab is used for breast cancer patients with high expression levels of HER2 (human epidermal growth factor receptor 2)/neu; however, it has no effect on cancers with low levels of HER2/neu. SM (solamargine), a major steroidal alkaloid glycoside purified from Solanum incanum, triggered apoptosis of breast cancer cells (MCF-7 and SK-BR-3 cells) and non-cancerous breast epithelial cells (HB...

Horn MEC, Brain E, Gregg I, Yealland SK, Inglis JM. Respiratory viral infection in childhood. A survey in general practice, Roehampton 1967-72. J Hyg 1975 ;74:157-68. 2 Mitchell I, Inglis H, Simpson H. Viral infections in wheezy bronchitis and asthma in children. Arch Dis Child 1976;51 :707-11. 3 Williams H, McNicol KN. Prevalence, natural history and relationship of wheezy bronchitis and asthm...

Bio-inspired techniques are used for synthesis in terms of application, green chemical research, facile, and eco-friendly chemistry study silver nanostructures utilizing plant extracts as natural reducing/stabilization solid adjuvants without the use toxic damaging reagents. The present investigates biosynthesis Ag nanoparticles via mediation methanolic extract Heracleum persicum seeds, any sta...

Streptokinase (SK) is a bacterial protein used clinically as a thrombolytic agent in humans. Administration of SK causes a rapid increase in the frequency of anti-SK T cells and the titre of specific anti-SK antibodies that, on subsequent administration of SK, may neutralize the activity of the drug or elicit allergic-type reactions. By locating and modifying the immunogenic T-cell epitopes wit...

Breast cancer (BCa) is one of the leading health problems among women. Although significant achievements have led to advanced therapeutic success with targeted therapy options, more efforts are required for different subtypes tumors and according genomic, transcriptomic, proteomic alterations. This study underlines role microRNA-21 (miR-21) in metastatic MDA-MB-231 breast cells. Following knock...

This data paper contains information about the in vivo model for peritoneal implants used in the paper "Tumor-environment biomimetics delay peritoneal metastasis formation by deceiving and redirecting disseminated cancer cells" (De Vlieghere et al., 2015) [1]. A double in vivo selection of SK-OV-3 Luc human ovarian cancer cell line was used to create SK-OV-3 Luc IP1 and SK-OV-3 Luc IP2 cell lin...

To study the mechanism of tea polyphenols (TP)-induced apoptosis of breast cancer cells. Proliferation of MCF-7 and SK-BR-3 cells was evaluated by MTT assays. Cellular ultrastructure was examined by electron microscopy. Apoptosis was detected by TUNEL. PCNA、 Cyclin D1、 Cyclin E and Survivin expression was measured by Western blot. Cell proliferation was significantly inhibited by TP. Spindle an...