The species of Pimpinella, one the largest genera family Apiaceae, are traditionally cultivated for medicinal purposes. In this study, high-throughput double digest restriction-site associated DNA sequencing technology (ddRAD-seq) was used to identify single nucleotide polymorphisms (SNPs) in eight Pimpinella from Iran. After double-digestion with enzymes HpyCH4IV and HinfI, a total 334,702,966...

Objective: Numerous single nucleotide polymorphisms (SNPs) have been identified as genetic contributors to atrial fibrillation (AF). The aim of this study was investigate the effects genome-wide N 6 -methyladenosine (m A)-SNPs on AF. Method: m A-SNPs were by analysis raw data from published AF GWAS datasets and list AVar database. Expression quantitative trait loci (eQTL) conducted evaluate gen...

The bovine leptin (LEP) gene was widely used as a candidate gene for molecular selection to improve productivity traits of cattle. This study was carried out to identify single nucleotide polymorphisms (SNPs) in the LEP gene of Sumba Ongole (SO, Bos indicus) cows using sequencing method. A total of 31 animals were used in this study for analyses. Research showed that total of 16 SNPs w...

Abstract. Hatta ANNL, Sukma D, Maskromo I, Sudarsono S. 2023. Validated SNAP markers based on the CYP P450 87 A3 gene in coconut (Cocos nucifera) are associated with yearly stem height increase. Biodiversitas 24: 2503-2512. Tall and dwarf coconuts types used worldwide as parents hybrid production, they differ their height. The of is estimated 11 leaf scars length. essential stem-height increase...

Despite improving cure rates in childhood acute lymphoblastic leukemia (ALL), therapeutic side effects and relapse are ongoing challenges. These can also affect the central nervous system (CNS). Our aim was to identify germline gene polymorphisms that influence risk of CNS events. Sixty single nucleotide (SNPs) 20 genes were genotyped a Hungarian non-matched ALL cohort 36 cases with chemotherap...

Single-nucleotide polymorphisms (SNPs) in the Toll-like receptor 4 (TLR4) gene have been documented type 2 diabetes mellitus (T2DM) and other diseases Saudi population. We investigated relationship between rs11536889, rs4986790, rs4986791 SNPs TLR4 T2DM population; 105 patients with healthy controls were analyzed. The was amplified through PCR, followed by restriction fragment length polymorphi...

mannose-binding lectin (mbl) is a ca⁺² -dependent collagenous lectin, that is produced by liver and mediates innate immune responses by opsonization of pathogens. the serum level of mbl varies widely among healthy individuals, ranging from 0.05 µg/ml (or lower) to over 5 µg/ml, mainly depending on genetic variation. this study has examined promoter and exon 1 of mbl2 genotype among 117 iranian ...

Although genetic variations rs780094 and rs1260326 of the glucokinase regulatory protein gene (GCKR) could be associated with lipid profile imbalance, their influence on acute ischemic stroke (AIS) risk has not yet been established. The aim this study was to investigate GCKR single nucleotide polymorphisms (SNPs) parameters in patients AIS, evaluate association these SNPs AIS. In a case-control...

background: multiple sclerosis (ms), a chronic inflammatory demyelinating disorder with neurodegenerative aspects, is more common among young adults, particularly women. methods: this molecular study was designed to investigate the il-7r α chain gene in iranian ms patients. we studied 60 ms patients, diagnosed based on 2005 r-mcdonald criteria and 60 apparently healthy individuals as the contro...