نتایج جستجو برای: single nucleotide polymo rphisms

تعداد نتایج: 949918  

P48 protein of Mycoplasma agalactiae is used to diagnose infection and was identified as potential vaccine candidate. According to the genetic nature of mycoplasma and variable sensitivity in P48-based serological diagnosis tests, intra species variation of P48 nucleotide sequence investigated in 13 field isolates of difference province of Iran along with three vaccine strains. Samples were col...

Journal: :Human heredity 2012
Jurg Ott Zhe Liu Yuanyuan Shen

BACKGROUND/AIMS We consider the situation that multiple genetic variants are underlying a heritable trait and assume that each contributes to the trait only to a small degree. The aim is to develop a statistical test for disease association of these multiple variants. METHODS We expect that p values resulting from a genome-wide case-control association analysis will fall into two classes: tho...

2015
Mark Achtman Zhemin Zhou Xavier Didelot Helge Thorsten Lumbsch

In 2013 Zhou et al. concluded that Salmonella enterica serovar Agona represents a genetically monomorphic lineage of recent ancestry, whose most recent common ancestor existed in 1932, or earlier. The Abstract stated 'Agona consists of three lineages with minimal mutational diversity: only 846 single nucleotide polymorphisms (SNPs) have accumulated in the non-repetitive, core genome since Agona...

2015
Hilary C Martin Ryan Christ Julie G Hussin Jared O'Connell Scott Gordon Hamdi Mbarek Jouke-Jan Hottenga Kerrie McAloney Gonnecke Willemsen Paolo Gasparini Nicola Pirastu Grant W Montgomery Pau Navarro Nicole Soranzo Daniela Toniolo Veronique Vitart James F Wilson Jonathan Marchini Dorret I Boomsma Nicholas G Martin Peter Donnelly

Several studies have reported that the number of crossovers increases with maternal age in humans, but others have found the opposite. Resolving the true effect has implications for understanding the maternal age effect on aneuploidies. Here, we revisit this question in the largest sample to date using single nucleotide polymorphism (SNP)-chip data, comprising over 6,000 meioses from nine cohor...

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