in this study, we discuss the capacitated facility location-allocation problem with uncertain parameters in which the uncertainty is characterized by given finite numbers of scenarios. in this model, the objective function minimizes the total expected costs of transportation and opening facilities subject to the robustness constraint. to tackle the problem efficiently and effectively, an effici...

background: rna plays key role in many aspects of biological processes and its tertiary structure is critical for its biological function. rna secondary structure represents various significant portions of rna tertiary structure. since the biological function of rna is concluded indirectly from its primary structure, it would be important to analyze the relations between the rna sequences and t...

a single nucleotide polymorphism (snp) in cd24 has been associated with multiple sclerosis (ms) in a population based study. this snp results in the replacement of alanine (cd24a) by valine (cd24v) at amino acid 57 in the resulting polypeptide chain. in the current study, the genotyping of this snp and its contribution to ms in 217 patients and 200 healthy individuals of an iranian population w...

the potential of marine actinobacteria particularly streptomyces as a single cell protein (scp) feed for the growth of ornamental fish, xiphophorus helleri has been investigated. the streptomyces strains used as scp were isolated from the marine sponges, namely callyspongia diffusa , mycale mytilorum , tedania anhelans and dysidea fragilis . six scp feeds were prepared and their effects were co...

in this paper a single server queuing production system is considered which is subject to gradual deterioration. the system is discussed under two different deteriorating conditions. a planning horizon is considered and server which is a d/m/1 queuing system is gradually deteriorates through time periods. a maintenance policy is taken into account whereby the server is restored to its initial c...

decisions relating to most irrigation-planning problems need to be made in the face of hydrologic uncertainties, which make the irrigation-planning problem more complex. the uncertainties can be tackled by formulating the problem as fuzzy linear programming (flp). in the present study, single objective fuzzy linear programming (soflp) irrigation planning model was formulated for deriving the op...

abstract background: correction of severe kyphosis is a challenging operation in spinal surgery. a two stage operation has been commonly used: anterior release and decompression followed by posterior correction and fusion. we describe the posterior vertebral osteotomy technique for correction of severe and rigid kyphosis through posterior-only approach. methods: twelve patients (six male and si...

aim : leptin is a 16 kda polypeptide hormone which secreted by adipose tissue and has an important role in energy balance, insulin pathway and inflammation, because of that it may play an important role in colorectal cancer (crc). leptin exerts its effect through the leptin receptor (lepr) a member of the class i cytokine receptor family. background : we have investigated whether glutamine to a...

abstract background von willebrand disease (vwd) is an autosomally inherited bleeding disorder with the prevalence of 1% based on population studies. the disease phenotype is due to quantitative and structural/functional defects in von willebrand factor (vwf) which is a glycoprotein with essential role as a carrier of fviii in circulation and also it serves the function as hemostasis regulator....

In this paper, we focus on outsourcing activities optimization problem in single period setting. In some situations, capacity planning or outsourcing is a one-time event and can be modeled as a single period problem. The aim of this research is to balance the trade-off between two echelons of a supply chain consisting of a single outsourcer and a single subcontractor. Each part is composed of a...