background: hydroxymethylglutaryl‑coenzyme a reductase inhibitors (statins) are antihyperlipidemic drugs with an established efficacy in stabilizing atherosclerotic plaques and preventing atherogenesis and reducing cardiovascular events. the purpose of this study was to determine the effect of simvastatin on serum vitamin d status in dyslipidemic patients as vitamin d status has an impact on mo...

INTRODUCTION Elevated interleukin (IL)-6 occurs in patients with active rheumatoid arthritis (RA), which has been shown to lead to a decrease in cytochrome P450 (CYP) enzyme activity and alterations in drug concentrations metabolized by CYP. IL-6 signaling blockade by IL-6 receptor (IL-6R) antagonists may reverse this effect of IL-6 and restore CYP activity. This study evaluated the pharmacokin...

Methods: Twenty-four rats were divided into 4 groups, according to the treatment received over the 13 days before and after ligature insertion around first lower molar in order to induce periodontal disease (PD): Ss (Simvastatin-Simvastatin); Sw (Simvastatin-Water); Ws (Water-Simvastatin) and Ww (Water-Water). Simvastatin was administered by gavage (35mg/Kg/day). After euthanasia, radiographic,...

The aim of study was to investigate the anti-proliferative and inflammatory effects atorvastatin, rosuvastatin, simvastatin in lung cancer. statins were investigated Vero, BEAS-2B, A549 cell lines. In addition expressions BAX, BCL-2, TNFα, IL-10, IL-6, protein levels IL-6 determined. Cell viability MDA also measured. While numbers groups with low doses found be approximately 1x106/mL, prolifera...

BACKGROUND Studies have described the effects of segmental muscle vibration (SMV) on brain plasticity and corticomotor excitability. Information on the treatment-induced effects of SMV in stroke patients is, however, still limited. OBJECTIVES To assess whether the application of SMV to ankle dorsiflexor muscles of chronic stroke patients can improve walking. METHODS Forty-four patients were...

Purpose: To study the effect of simvastatin on behavioral performance in a rat model autism, and its hippocampal brain-derived BDNF-TrkB pathway.
 Methods: Twelve rats with valproic acid (VPA)-induced autism were randomly divided into group group, while six healthy served as normal control group. Rats received drug (5 mg/kg) via i.p. route, injected equivalent volume saline place simvastat...

INTRODUCTION Between 2010 and 2012, the US Food and Drug Administration and Health Canada issued warnings to healthcare professionals emphasizing the increased risk of muscle problems with high-dose simvastatin. OBJECTIVE To measure the impact of the Health Canada safety warning regarding dose-dependent adverse effects of simvastatin on prescribing of low, medium, and high doses of simvastati...

background adiponectin is an adipose tissue-derived protein with anti-inflammatory properties. statins are a class of cholesterol-lowering drugs, widely used for treatment of cardiovascular diseases. objectives in the current study, we aimed to assess the effects of simvastatin on serum levels of adiponectin in patients with dyslipidemia, recruited from ghaem hospital, mashhad, iran. materials ...