Esomeprzole and naproxen are available in tablet dosage form in the ratio 1:25. Two simple, accurate, precise and economic methods; simultaneous equation method and multicomponent method have been described for the simultaneous estimation of esomeprzole and naproxen in tablet dosage form. Absorption maxima of esomeprzole and naproxen in distilled water were found to be 301.0 nm and 262.0 nm res...