The effect of high doses of vitamin E (Vit.E; 400 units/ day) on ornithine decarboxylase (ODC) activity and regression of small intestinal metaplasia (SIM) was studied in a 1-year double-blind intervention trial. Biochemical and morphological parameters were estimated in 14 evaluable SIM patients of 18 in the Vit.E group and in 16 of 18 intestinal metaplasia patients enrolled in control group (...

Endoreplication, also known as endoreduplication, is a phyogenetically widespread modified version of the cell cycle in which DNA replication is not followed by cell division. The SIAMESE (SIM) gene of Arabidopsis thaliana encodes the founding member of a novel class of plant-specific cyclin-dependent kinase (CDK) inhibitors and is a key regulator of endoreplication during the development of tr...

System design usually begins with a high-level software simulation which is later refined to a detailed hardware description. A simulation framework can facilitate this process by automating certain hardware abstractions, providing important debugging support, and allowing the transition from a high-level simulation to a low-level hardware description to occur within a single code base. This pa...

Structured illumination microscopy (SIM) is a wide-field technique in fluorescence microscopy that provides fast data acquisition and two-fold resolution improvement beyond the Abbe limit. We observed a further resolution improvement using the nonlinear emission response of a fluorescent protein. We demonstrated a two-beam nonlinear structured illumination microscope by introducing only a minor...

Super-resolution fluorescence microscopy is distinct among nanoscale imaging tools in its ability to image protein dynamics in living cells. Structured illumination microscopy (SIM) stands out in this regard because of its high speed and low illumination intensities, but typically offers only a twofold resolution gain. We extended the resolution of live-cell SIM through two approaches: ultrahig...

In this paper, we design SIM, a protocol that integrates three distinct mechanisms – Selective participation, Intra-group transmission adjustment, and Menu adaptation – to solve the general multicast congestion control problem. We argue that only a solution that includes elements of each mechanism can scale and adapt to heterogeneity in network and receiver characteristics. In our protocol, the...

Critical issues in the acceptance of wireless services are the authentication and authorisation to these services. This paper presents the SIM as device for Mobile phone/SIM card based authentication. The mobile phone can be used for physical access (admittance) and service access using near field communication (NFC). It has the potential becoming the identity provider in the virtual/electronic...

The Srs2 DNA helicase of Saccharomyces cerevisiae affects recombination in multiple ways. Srs2 not only inhibits recombination at stalled replication forks but also promotes the synthesis-dependent strand annealing (SDSA) pathway of recombination. Both functions of Srs2 are regulated by sumoylation--sumoylated PCNA recruits Srs2 to the replication fork to disfavor recombination, and sumoylation...

Tendon rupture induces an inflammatory response characterized by release of pro-inflammatory cytokines and impaired tendon performance. This study sought to investigate the therapeutic effects of simvastatin-loaded porous microspheres (SIM/PMSs) on inflamed tenocytes in vitro and collagenase-induced Achilles tendinitis in vivo. The treatment of SIM/PMSs in lipopolysaccharide (LPS)-treated tenoc...

We test the Secondary Infall Model (SIM) by direct comparison with the results of Nbody simulations. Eight cluster-size and six galactic-size dark matter haloes have been selected at z = 0 and re-simulated with high resolution. Based on their density profiles at the initial redshift, we compute their evolution by the SIM, assuming a simple prescription for the angular momentum. A comparison of ...