Extracts from the seeds of milk thistle, Silybum marianum, are known commonly as silibinin and silymarin and possess anticancer actions on human prostate carcinoma in vitro and in vivo. Seven distinct flavonolignan compounds and a flavonoid have been isolated from commercial silymarin extracts. Most notably, two pairs of diastereomers, silybin A and silybin B and isosilybin A and isosilybin B, ...

Silymarin is obtained from the seeds of Silybum marianum (milk thistle), an edible plant that has been used medicinally from ancient times for the treatment of various liver disorders. It is widely prescribed by herbalists and has almost no known side effects. The plant is native to the Mediterranean and grows throughout Europe, North America, India, China, South America, Africa and Australia. ...

The present study investigated the effect of silibinin, the principal potential anti-inflammatory flavonoid contained in silymarin, a mixture of flavonolignans extracted from Silybum marianum seeds, on palmitate-induced insulin resistance in C2C12 myotubes and its potential molecular mechanisms. Silibinin prevented the decrease of insulin-stimulated 2-NBDG (2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-...

This study was performed to investigate the effect of Ag+ as an elicitor on the activity of antioxidant enzymes, content of H2O2, accumulation of total tocopherol and antioxidant activity in hairy root cultures of Silybum marianum (L.) Gaertn. The hairy roots were treated with 2 mM Ag+. The treated and non-treated hairy roots were harvested in the same time and data on H2O2 content, DPPH, tocop...

Terapötik özelliklerinden dolayı Silybum marianum'un toprak üztünde kalan kısımları geleneksel olarak halk hekimliğinde kullanılmaktır. Bu çalışmanın amacı, marianum üstü kısımlarının metanol ekstraktlarının antioksidan kapasitesini ve toplam fenol flavonoid içeriklerini belirlemektir. belirlemek için DPPH (2, 2-difenil-1-pikrilhidrazil) serbest radikal süpürme indirgeme kapasitesi deneyleri ku...

Silymarin, a flavonolignan from the seeds of ‘milk thistle’ (Silybum marianum), has been widely used from ancient times because of its excellent hepatoprotective action. It is a mixture of mainly three flavonolignans, viz, silybin, silidianin, and silychristine, with silybin being the most active. Silymarin has been used medicinally to treat liver disorders, including acute and chronic viral he...

Extracts from the seeds of milk thistle, Silybum marianum , are known commonly as silibinin and silymarin and possess anticancer actions on human prostate carcinoma in vitro and in vivo. Seven distinct flavonolignan compounds and a flavonoid have been isolated from commercial silymarin extracts. Most notably, two pairs of diastereomers, silybin A and silybin B and isosilybin A and isosilybin B,...