We report evidence that murine NK cells express a functional Fc gamma RII encoded by the Fc gamma RII alpha gene. Several lines of indirect evidence indicate that freshly obtained NK cells from mice of several strains bear a functional Fc gamma RII: (a) anti-Fc gamma RII antibody 2.4G2 detects a small but significant proportion of sIg- cells and a small proportion of the 2.4G2+ cells are includ...

The elongation phase of transcription by RNA Polymerase II (Pol II) involves numerous events that are tightly coordinated, including RNA processing, histone modification, and chromatin remodeling. RNA splicing factors are associated with elongating Pol II, and the interdependent coupling of splicing and elongation has been documented in several systems. Here we identify a conserved, multi-domai...

Intracranial headaches, including migraines, are mediated by nociceptive activation of the trigeminal nucleus caudalis (TNC), but the precise mechanisms are poorly understood. We previously demonstrated that selective blockage of spinal sigma-1 receptors (Sig-1R) produces a prominent antinociceptive effect in several types of pain models. This study evaluates whether the Sig-1R antagonist (BD10...

The third meeting of the Special Interest Group (SIG) for Text Mining was held in conjunction with ISMB in Australia this year, following the 2001 meeting in Copenhagen and the 2002 meeting in Edmonton. The Text Mining SIG has been organized by the BioLINK group (http://www.pdg.cnb.uam.es/BioLINK), with its main contributors Lynette Hirschman (MITRE, Bedford, MA, USA) and Alfonso Valencia (CNB,...

A User Interface Description Language (UIDL) is a formal language used in Human-Computer Interaction (HCI) in order to describe a particular user interface independently of any implementation. Considerable research effort has been devoted to defining various meta-models in order to rigorously define the semantics of such a UIDL. These meta-models cover different aspects: context of use (user, p...

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As the previous and current chair of the British Association for Sexual Health and HIV (BASHH) HIV Special Interest Group (SIG), we will summarise the activities of this busy, diverse SIG. We have about 20 members who communicate regularly by email and include trainee, community, nursing and pharmacy representation. The ‘HIV SIG’ is also involved in activities related to hepatitis B and C, work...

We showed that the Ad-sig-TAA/ecdCD40L vaccine induces a tumor suppressive immune response to the hMUC-1 and rH2N tumor-associated self Ags (TAA) and to the Annexin A1 tumor vascular Ag, even in mice in which anergy exists to these Ags. When the TAA/ecdCD40L protein is given s.c. as a boost following the Ad-sig-TAA/ecdCD40L vector, the levels of the TAA-specific CD8 T cells and Abs increase dra...

In this paper the problem of computing a minimum dominating set of a Shiftable Interval Graph (SIG) is studied. SIG's can be considered a generalization of interval graphs, in the sense that a SIG identifies a whole family of interval graphs. An optimization problem defined on a SIG consists in determining an interval graph of the family which optimizes the value of the chosen measure. In this ...

Genomic data are becoming increasingly valuable as we develop methods to utilize the information at scale and gain a greater understanding of how genetic information relates to biological function. Advances in synthetic biology and the decreased cost of sequencing are increasing the amount of privately held genomic data. As the quantity and value of private genomic data grows, so does the incen...