The ability of a clonal hematopoiesis-supportive bonemarrow stromal cell line GBlneor to engraft and alter the microenvironment-induced anemia of SI/Sl ’ mice was studied. Prior to stromal cell transplantation. SI/SId mice received 1 Gy total body irradiation (TBI) and 1 3 Gy to the right hind limb. Two months after intravenous (IV) injection of 5 x 1 GBlneor cells. 54.4% ± 1 7.0% donor origin ...

BACKGROUND Respiratory syncytial virus (RSV) causes significant mortality in patients with hematological diseases, but diagnosis and treatment are uncertain. METHODS We retrospectively identified RSV-infected patients with upper or lower respiratory tract infection (RTI) by culture, antigen testing, and polymerase chain reaction from November 2002 through April 2007. Patients with severe immu...

We present recent improvements in the performance of the reconstruction of non-prompt track in the SiD Detector Concept Design, including initial results on the effect of longitudinal segmentation in the SiD tracker. We also describe a generic tracking validation package developed at SCIPP.

This paper describes the Sharp Intelligent Dictionary (SID), an English-Japanese glossing system for Japanese readers and learners of English. SID uses a variety of lightweight analysis techniques, a large bilingual dictionary and a prioritised model of collocations to present informed guesses about the best translations of words and expressions in their context.

Rate constants for the unimolecular decomposition of peptide monomer and dimer ions by thermal and surface-induced dissociation (SID) are measured and compared. Rate constants for thermal dissociation are measured in a heated wide-bore capillary flow reactor attached in front of the capillary leading into the mass spectrometer. Thermal decomposition of the leucine enkephalin ion (YGGFL)H+ is ob...

The ability of a clonal hematopoiesis-supportive bonemarrow stromal cell line GBlneor to engraft and alter the microenvironment-induced anemia of SI/Sl ’ mice was studied. Prior to stromal cell transplantation. SI/SId mice received 1 Gy total body irradiation (TBI) and 1 3 Gy to the right hind limb. Two months after intravenous (IV) injection of 5 x 1 GBlneor cells. 54.4% ± 1 7.0% donor origin ...

Cancer cell invasion is an obligatory step for metastatic dissemination that contributes to rapid relapse and a poorer survival in triple negative breast cancer (TNBC) patients. Development of novel therapeutic strategies to block tumor invasion is an unmet need in the treatment of cancer. We reported that the selective inhibition of the PAH2 domain of SIN3A protein function markedly suppressed...

Mass spectrometry has emerged as a useful tool in the study of proteins and protein complexes. It is of fundamental interest to explore how the structures of proteins and protein complexes are affected by the absence of solvent and how this alters with increasing time in the gas phase. Here we demonstrate that a range of protein and protein complexes can be confined within the Trap T-wave regio...

HYPOTHESIS Infants with rotational abnormalities of the midgut mesentery are at high risk for gastroesophageal reflux disease (GERD) and for sudden infant death (SID) from GERD. DESIGN A survey of the prevalence of GERD and the risk factor for SID from GERD in a case series of infants treated for congenital anomalies that include intestinal malrotation. Eighty-one (89%) of the infants studied...

Triple negative breast cancer (TNBC) frequently relapses locally, regionally or as systemic metastases. Development of targeted therapy that offers significant survival benefit in TNBC is an unmet clinical need. We have previously reported that blocking interactions between PAH2 domain of chromatin regulator Sin3A and the Sin3 interaction domain (SID) containing proteins by SID decoys result in...