Nowadays, the necessity of manufacturers’ response to their customers’ needs and their fields of activities have extended widely. The cellular manufacturing systems have adopted reduced costs from mass-production systems and high flexibility from job-shop manufacturing systems, and therefore, they are very popular in modern manufacturing environments. Manufacturing systems, in addit...

Viral infections cause many different diseases stemming both from well-characterized viral pathogens but also from emerging viruses, and the search for novel viruses continues to be of great importance. High-throughput sequencing is an important technology for this purpose. However, viral nucleic acids often constitute a minute proportion of the total genetic material in a sample from infected ...

Finishing is rate limiting for genome projects, and improvements in the efficiency of complete genome-sequence compilation will require improved protocols for gap closure. Here we report a novel approach for extending shotgun contigs and closing gaps that we termed PCR-assisted contig extension (PACE). PACE depends on the capture of rare mismatched interactions that occur between arbitrary prim...

The taxonomic composition of environmental communities is an important indicator of their ecology and function. We used a set of protein-coding marker genes, extracted from large-scale environmental shotgun sequencing data, to provide a more direct, quantitative, and accurate picture of community composition than that provided by traditional ribosomal RNA-based approaches depending on the polym...

Companies and firms, nowadays, due to mounting competition and product diversity, seek to apply virtual cellular manufacturing systems to reduce production costs and improve quality of the products. In addition, as a result of rapid advancement of technology and the reduction of product life cycle, production systems have turned towards dynamic production environments. Dynamic cellular manufact...

The regulation and maintenance of the cellular lipidome through biosynthetic, remodeling, and catabolic mechanisms are critical for biological homeostasis during development, health and disease. These complex mechanisms control the architectures of lipid molecular species, which have diverse yet highly regulated fatty acid chains at both the sn1 and sn2 positions. Phosphatidylcholine (PC) and p...