The intellectual backdrop motivating our effort to clone lin-4 (Lee et al., 1993) had nothing to do with questions about noncoding RNAs or antisense gene regulation. We were simply curious about an interesting worm mutant, and everything we found out about it was unexpected. We consider ourselves very lucky to happen to have chosen lin-4 to study. In fact, good fortune appeared at many steps be...

What does it mean to be a ‘‘just’’ and ‘‘caring’’ society when we have only limited resources to meet virtually unlimited health care needs? In Just Caring. Health Care Rationing and Democratic Deliberation Leonard Fleck identifies health care rationing as the moral problem of contemporary health care. At present, millions of Americans go without health insurance, thousands of whom die prematur...

We study how the speed of spread for an integrodifference equation depends on the dispersal pattern of individuals. When the dispersal kernel has finite variance, the central limit theorem states that convolutions of the kernel with itself will approach a suitably chosen Gaussian distribution. Despite this fact, the speed of spread cannot be obtained from the Gaussian approximation. We give sev...

OBJECTIVES Manual response time (RT) and P300 event-related potential (ERP) measures were recorded in a Stroop color naming task to determine if previous results with vocal responses would be obtained using an arbitrary stimulus-response (S-R) mapping. METHODS Subjects (n = 32) were instructed to respond to the display color of a word but to ignore its meaning. Display color was congruent, ne...