With increasing marine transportation and logistics, the ship autopilot has become much more important not only to lower the seaman's operating intensions, but also to reduce the seaman's deployment. It is still a challenge to design ship coursekeeping controller because of ship's uncertain dynamics and time-varying environmental disturbance. This study focuses on backstepping adaptive course-k...

This article explores employee perspectives on effective leader ship in UK Further Education (FE). Studies on leader ship effectiveness typically seek either to specify the individual qualities of ‘heroic’ leaders or, increasingly, to highlight the collective nature of ‘post-heroic’ leader ship. While these discourses are frequently seen as dichotomous and competing, our research found that FE ...

The SH2 domain-containing inositol 5'-phosphatase-1 (SHIP) has the potential to modulate multiple signaling pathways downstream of receptors that impact hematopoietic stem cell (HSC) biology. Therefore, we postulated that SHIP might play an important role in HSC homeostasis and function. Consistent with this hypothesis, HSC proliferation and numbers are increased in SHIP(-/-) mice. Despite expa...

Abstract: Along with increasing marine transportation and logistics, the ship autopilot has become much important not only to lower the seaman's operating intensions, but also to reduce the seaman's deployment. It is still a challenge to design ship course-keeping controller because of ship's uncertain dynamics and time-varying environmental disturbance. This study focuses on backstepping adapt...

Given a schedule of trains, the locomotive planning (or scheduling) problem (LPP) is to determine the minimum cost assignment of locomotive types to trains that satisfies a number of business and operational constraints. Once this is done, the railroad has to determine the sequence of trains to which each locomotive is assigned by unit number so that it can be fueled and serviced as necessary. ...

Src-homology-2-containing inositol-5´-phosphatase, SHIP (also known as SHIP1), is a tumor suppressor that negatively regulates the phosphatidylinositol 3-kinase (PI3K) pathway by hydrolyzing the PI3K-generated second messenger phosphatidylinositol-3,4,5-triphosphate (PIP 3) to PI-3,4-P 2. SHIP expression is restricted primarily to hematopoietic cells, but has also been reported in mesenchymal s...

BACKGROUND Th2-dominated inflammatory response in the airway is an integral component in the pathogenesis of allergic asthma. Accumulating evidence supports the notion that the phosphoinositide 3-kinase (PI3K) pathway is involved in the process. We previously reported that SHIP-1, a negative regulator of the PI3K pathway, is essential in maintaining lung immunohomeostasis, potentially through r...

Two signaling molecules have been implicated in the modulation of immune receptor activation by inhibitory coreceptors: an inositol polyphosphate 5'-phosphatase, SHIP, and a tyrosine phosphatase, SHP-1. To address the necessity, interaction, or redundancy of these signaling molecules, we have generated SHP-1- or SHIP-deficient B cell lines and determined their ability to mediate inhibitory sign...

fter 20-30 years ships are at the end of their effective service life [9] and they are then dismantled. Ship dismantling in the US is quite different from in developing countries, and ship deconstruction costs are much higher in the US. The ship deconstructors in developing countries earn significant profits because of lower recycling costs of the ships and higher resale values of the scrap. Pr...

We recently purified and cloned a 145-kDa protein that becomes tyrosine phosphorylated and associated with Shc in response to multiple cytokines. Based on its predicated amino acid sequence and its enzymatic activity, we have called this protein SHIP, for Src homology 2-containing inositol phosphatase. To gain further insight into the intracellular pathways that this putative signal transductio...