In this work we propose a novel approach to model order reduction for incompressible fluid flows that focuses on the spatio-temporal description of the stresses on the surface of a body, i.e. of the wall shear stress and of the wall pressure. The spatial representation of these two variables is given by a compact set of “wall basis functions”, i.e. elementary basis functions defined on the wall...

Leukocyte adhesion through L-selectin to peripheral node addressin (PNAd, also known as MECA-79 antigen), an L-selectin ligand expressed on high endothelial venules, has been shown to require a minimum level of fluid shear stress to sustain rolling interactions (Finger, E.B., K.D. Puri, R. Alon, M.B. Lawrence, V.H. von Andrian, and T.A. Springer. 1996. Nature (Lond.). 379:266-269). Here, we sho...

INTRODUCTION AND OBJECTIVES Local factors may influence neointimal proliferation following conventional stent implantation. In this study, the relationship between wall shear stress and luminal loss after coronary stenting was assessed using a combination of angiography, intravascular ultrasound, and computational fluid dynamics. PATIENTS AND METHOD Seven patients with de novo right coronary ...

The effect of spatially varying shear on transport to the wall of a two-dimensional branch was examined, using oxygen as the test solute and the results of earlier fluid mechanical calculations to provide the shear profiles in a region characterizing the aortic bifurcation. The numerical technique employed allowed both blood-phase and mural resistances to solute uptake to be treated simultaneou...

In this present work, a cost optimization has been done for r/c structural system by genetic algorithm method. In the optimization problem the shear-wall dimensions has been considered as design variables and it has been aimed at searching the optimum shear-wall dimensions that minimize total material cost of shear-wall. The constraints of structural optimization problem are constructed accordi...

Leukocytes roll on selectins at nearly constant velocities over a wide range of wall shear stresses. Ligand-coupled microspheres roll faster on selectins and detach quickly as wall shear stress is increased. To examine whether the superior performance of leukocytes reflects molecular features of native ligands or cellular properties that favor selectin-mediated rolling, we coupled structurally ...

Nowadays, steel shear walls are used as efficient lateral-load-resistant systems due to their high lateral stiffness and carrying capacity. In this paper, the effect of substituting a shape memory alloy (SMA) material is investigated instead of using conventional steel in the shear wall. A numerical study is conducted using finite element method (FEM) by OpenSees software. For this purpose, at ...

BACKGROUND An autogenous arteriovenous fistula is the optimal vascular access for hemodialysis. In the case of brachiocephalic fistula, cephalic arch stenosis commonly develops leading to access failure. We have hypothesized that a contribution to fistula failure is low wall shear stress resulting from post-fistula creation hemodynamic changes that occur in the cephalic arch. METHODS Twenty-t...

PURPOSE The precise role played by hemodynamics, particularly wall shear stress, in the development and progression of vascular disease remains unclear, in large part because of a lack of in vivo studies with humans. Although technical challenges remain for noninvasively imaging wall shear stresses in humans, vascular anatomy can be imaged with sufficiently high resolution to allow reconstructi...

To interrelate in vivo wall shear stress, endothelial microfilament bundle formation, and atherosclerosis localization, we used a mild abdominal aortic stenosis in 11 beagles to produce a range of wall shear stresses above and below the constriction. Six of the beagles were fed standard animal chow supplemented with 5% cholesterol and 10% coconut oil. Wall shear stresses, endothelial microfilam...