Numerical simulation analyzes the mixed convection flow of $$\hbox {Al}_{2}\hbox {O}_{3}{-}\hbox {Cu}{-}\hbox {H}_{2}\hbox {O}$$ (aluminium oxide–copper–water) hybrid nanofluid inside a split lid-driven trapezoidal cavity. A triangular-shaped cold obstacle is placed The horizontal base cavity kept cold, whereas side walls are chosen adiabatic. thermally active upper wall maintained at constant ...

objective: in a cavity prepared through endodontic surgery, application of a material to provide apical seal and prevent bacterial and tissue exudates is of great importance. the purpose of this study was to compare the sealing ability of biocalex with white mta, gray mta, and amalgam as root-end fillings. materials and methods: sixty-six single-rooted extracted human teeth were cleaned, shaped...

Generating non-classical states in macroscopic systems is a long standing challenge. A promising platform the context of this quest are novel hybrid based on magnetic dielectrics, where photons can couple strongly and coherently to excitations, although state therein yet be observed. We propose scheme generate magnetization cat state, i.e. quantum superposition two distinct directions, using co...

The bifunctional proline catabolic flavoenzyme, proline utilization A (PutA), catalyzes the oxidation of proline to glutamate via the sequential activities of FAD-dependent proline dehydrogenase (PRODH) and NAD(+)-dependent Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH) domains. Although structures for some of the domains of PutA are known, a structure for the full-length protein has no...

Dihydrolipoamide acyltransferase (E2), a catalytic and structural component of the three functional classes of multienzyme complexes that catalyze the oxidative decarboxylation of alpha-keto acids, forms the central core to which the other components attach. We have determined the structures of the truncated 60-mer core dihydrolipoamide acetyltransferase (tE2) of the Saccharomyces cerevisiae py...

Lon, also known as protease La, belongs to a class of ATP-dependent serine protease. It plays an essential role in degradation of abnormal proteins and of certain short-lived regulatory proteins, and is thought to possess a Ser-Lys catalytic dyad. To examine the structural organization of Lon, we performed an electron microscope analysis. The averaged images of Lon with end-on orientation revea...

While a monomer of the ubiquitous hormone insulin is the biologically active form in the human body, its hexameric assembly acts as an efficient storage unit. However, the role of water molecules in the structure, stability and dynamics of the insulin hexamer is poorly understood. Here we combine experimental data with molecular dynamics simulations to investigate the shape, structure and stabi...