The electrochemical CO2 reduction reaction (CO2RR) holds the promise to revolutionize chemical industry by producing value-added chemicals and fuels from water while storing renewable energy. However, catalyst design still remains one of major hurdles in field. This Perspective discusses current future contributions well-defined nanocatalysts improving CO2RR selectivity toward C2 products, part...

The aim of this study was to use a combined structure and pharmacophore modeling approach to extract information regarding dopamine D₁ receptor agonism and D₁/D₂ agonist selectivity. A 3D structure model of the D₁ receptor in its agonist-bound state was constructed with a full D₁ agonist present in the binding site. Two different binding modes were identified using (+)-doxanthrine or SKF89626 i...

Recent studies have demonstrated the high selectivity of neurons in primary auditory cortex (A1) and a highly sparse representation of sounds by the population of A1 neurons in awake animals. However, the underlying receptive field structures that confer high selectivity on A1 neurons are poorly understood. The sharp tuning of A1 neurons' excitatory receptive fields (RFs) provides a partial exp...