Background: Phosphodiesterase 3A (PDE3A) and phosphodiesterase 3B (PDE3B) play a critical role in the regulation of intracellular level of adenosine 3´,5´-cyclic monophosphate (cyclic AMP, cAMP) and guanosine 3´,5´-cyclic monophosphate (cyclic GMP, cGMP). Subsequently PDE3 inhibitors have shown to relax vascular and inhibit platelet aggregation in cardiovascular disease. Objectives: In th...

for an indoor non-directed line of sight optical wireless communication (nlos-owc) system we investigate the optimized lambertian order (olo) of light-emitting diodes (leds). we firstly derive an expression for the olo from a conventional lambertian led model. then, we analyze the indoor multi-cell nlos-owc channel characteristics including the optical power distribution and the multipath time ...

background the fas receptor/ligand system including soluble forms is the most important apoptotic initiator in the liver. dysregulation of this pathway may contribute to abnormal cell proliferation and cell death and is regarded as one of the mechanisms preventing the immune system from rejecting the tumor cells. objectives to analyze the role of fas system fas/ fas ligand (fas/ fasl) in the mu...

poly (ADP-ribose) polymerase catalytic domain. Braz. J. Med. Biol. Res. 30:923-928. 14.Mortensen, C. 1995. Clonagem e expressão de hormonios peptídicos humanos em vetores de expressão de baculovirus. Master’s degree dissertation. University of São Paulo, Chemistry Institute. 15.Moscardi, F. 1989. Use of viruses for pest control in Brazil: the case of the nuclear polyhedrosis virus of the soybea...

Renin, a highly specific aspartic proteinase originated from kidney, is a ratelimiting enzyme in renin-angiotensin system. Recently, we developed effective expression system for recombinant human (rh) renin using baculovirus-insect cell expression system, and simple and rapid assay method for rh-renin using internally quenched fluorogenic (IQF) substrate. Using the purified rh-renin and the IQF...

background: both azadirachtin and rotenone, two botanical pesticides have shown inhibit the growth of cultured insect cells. the inhibitory effect of rotenone on cell growth is through disruption of electron transport chain, but exact mechanism of effect of azadirachtin on growth of cell is unknown. this study was carried out to compare the effect of these phytochemical on oxygen consumption by...

introduction: hepatitis c virus (hcv) infection is a major public health problem which influences about 170 million people worldwide. different types of vaccines have been designed using hcv structural proteins to control the viral infection. the core nucleocapsid protein is one of the most conserved proteins and a desirable target for hcv vaccines, especially the protein-based vaccines. in cur...