PURPOSE Many epidemiologic studies indicate an increased incidence of certain vision threatening conditions in postmenopausal women. These data suggest that changes in sex steroid homeostasis may affect the physiology of the eye. To provide support to this hypothesis, the expression of estrogen receptor alpha (ERalpha) in human eye tissues was investigated. METHODS Complementary studies inclu...

Plasma binding globulins bind steroid hormones and are thought to regulate hormone access to tissues. Mammals have both sex steroid binding globulin (SSBG) and corticosteroid binding globulin (CBG). Birds, however, have no detectable SSBG, leading to the early conclusion that birds have no plasma regulation of sex steroids. CBG, however, can bind androgens with relatively high affinity. In bird...

Cytosol from rat and mouse adrenal glands has been shown to contain a macromolecule which binds estradiol, but not corticosterone or testosterone. The receptor. estrogen complex has a sedimentation coefficient of 8 S when centrifuged on low salt sucrose gradients. Centrifugation on 0.4 M KC1 gradients results in an 8 S + 4 S transformation. The estrogen-binding entity is, at least partially, a ...

host innate immunity can affect the clinical outcomes of helicobacter pylori infection, including gastritis, gastric ulcer, gastric adenocarcinoma, and malt lymphoma. nucleotide binding oligomerization domain (nod)-1 and -2 are two molecules of innate immunity which are involved in the host defense against h. pylori . this study aimed to evaluate the effect of the expression level of nod1 and n...

host innate immunity can affect the clinical outcomes of helicobacter pylori infection, including gastritis, gastric ulcer, gastric adenocarcinoma, and malt lymphoma. nucleotide binding oligomerization domain (nod)-1 and -2 are two molecules of innate immunity which are involved in the host defense against h. pylori . this study aimed to evaluate the effect of the expression level of nod1 and n...

Skeletal muscle can synthesize testosterone and 5α-dihydrotestosterone (DHT) from dehydroepiandrosterone (DHEA) via steroidogenic enzymes in vitro, but hormone levels and steroidogenic enzyme expression decline with aging. Resistance exercise has been shown to increase in plasma sex steroid hormone levels. However, it remains unclear whether resistance training can restore impaired steroidogeni...

The CYP19 gene encodes the enzyme aromatase, which plays a key role in the conversion of androgen to estrogen. The prostate is influenced by estrogen from peripheral sources as well as through aromatase activity in its stroma (1). There is evidence of elevated levels of aromatase activity and mRNA expression in stromal cells in prostate cancer as well as increasing evidence of cross-talk betwee...