Cortical spreading depression (CSD) is associated with severe hypoperfusion in mice. Using minimally invasive multimodal optical imaging, we show that severe flow reductions during and after spreading depression are associated with a steep decline in cerebral metabolic rate of oxygen. Concurrent severe hemoglobin desaturation suggests that the oxygen metabolism becomes at least in part supply l...

background and aims: mental disorders may negatively affect on the quality of life in hemodialysis patients and their response to treatment. the aim of present study was to examine the prevalence of depression and related risk factors in hemodialysis patients. methods: in this cross-sectional study, during june 2013 to september 2013, 217 patients with hemodialysis whom were admitted to kerman ...

This study modelled the economic impact of mirtazapine, compared to amitriptyline and fluoxetine, in the management of moderate and severe depression in the UK, as well as the costs related to discontinuation of antidepressant treatment. Decision models of the management of moderate and severe depression were developed from clinical trial data, resource use obtained from interviews with general...

BACKGROUND Guideline oriented treatment strategies of Major depressive disorder (MDD) improve treatment outcomes and reduce risks of chronicity and recurrence. AIMS Description of routine treatment reality and analysis of guideline fidelity in first episode MDD in Germany. Indicators: patients with severe or psychotic depression or severe psychiatric comorbidities' treatment by specialists, a...

Articles describing older persons' experiences of coping with severe depression are, to our knowledge, lacking. This article is methodologically grounded in phenomenological hermeneutics, inspired by Paul Ricoeur, and applies a descriptive design with in-depth interviews for producing the data. We included 18 older persons, 13 women and 5 men, with a mean age of 77.9 years, depressed to a sever...

We aimed to assess depressive symptoms in caregivers of patients with dementia, taking into account variables such as severity of dementia, sex, age, and financial state of the patient. We recruited 222 caregivers of patients with dementia from King Abdulaziz Medical City, Saudi Alzheimer's Disease Association, and online, from February to June 2017, and employed the Patient Health Questionnair...

Background: Studies done around the world since onset of pandemic have shown high levels psychological morbidity among healthcare workers (HCW). Psychological impact COVID-19 on HCW in Sri Lanka has not been assessed.
 
 Objectives: To assess distress, challenges and perceived needs (HCW) during a tertiary care hospital Lanka
 Methods: A cross sectional descriptive study was 394 ...

introduction: to determine the prevalence of depressive disorder and it's related factors in the patients with rheumatoid arthritis. methods: this cross-sectional study was conductd from april 2013 to august 2014.a total of 81 patients with rheumatoid arthritis (ra) were enrolled from rheumatology clinic, shahid beheshti hospital, kashan/ iran. the severety of depressive disorder was measured b...

objectives: the high number of cerebral palsy, the severe disability of this disorder, depression in disabilities, and long lasting effects of the child`s disability on the family especially mothers are the common issues. the purpose of this study was investigating the level of depression in mothers with cerebral palsy children and its related factors. methods: this caused comparative study was...