نتایج جستجو برای: severe combined immunodeficiency scid
تعداد نتایج: 787021 فیلتر نتایج به سال:
Human acute leukemia, with a chromosomal translocation involving chromosomes 4 and 11, t(4;llXq21;q23), is the most common form of leukemia in infants and responds very poorly to conventional therapy. A human CD19* mixed-lineage leukemia cell line with a t(4;llXq21;q23) translocation, RS4;11, disseminated and proliferated in the hematopoietic tissues and other organs of mice with severe combine...
IL-2 represents the dominant growth factor for T lymphocytes, and consequently plays a central role in the development of an immune response (reviewed in reference 1) . Additionally, this cytokine has been implicated in intrathymic T cell development (2, 3) . Severe combined immunodeficiency disease (SCID) t is a rare, heterogeneous, lethal congenital disorder characterized by severe impairment...
Hematopoiesis is a complex process involving hematopoietic stem cell (HSC) self-renewal and lineage commitment decisions that must continue throughout life. Establishing a reproducible technique that allows for the long-term ex vivo expansion of human HSCs and maintains self-renewal and multipotential differentiation will allow us to better understand these processes, and we report the ability ...
Although scid mice have been widely used for human HSC engraftment studies, the function of HSCs of scid mice has not been characterized. We hypothesized that the DNA repair defect of scid mice results in a stem cell defect that facilitates HSC engraftment. scid BM cells showed severely impaired repopulation potentials in the competitive repopulation assay. To assess the BM hematopoietic niche ...
Analysis of sites of newly integrated DNA in cellular genomes is important to several fields, but methods for analyzing and visualizing these datasets are still under development. Here, we describe tools for data analysis and visualization that take as input integration site data from our INSPIIRED pipeline. Paired-end sequencing allows inference of the numbers of transduced cells as well as th...
Severe combined immunodeficiency (SCID) syndromes are characterized by a block in T lymphocyte differentiation that is variably associated with abnormal development of other lymphocyte lineages (B and/or natural killer [NK] cells), leading to death early in life unless treated urgently by hematopoietic stem cell transplant. SCID comprises genotypically and phenotypically heterogeneous condition...
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