Follicular thyroid carcinoma is common in regions with insufficient iodine diets and represents approximately 10-20 % of all thyroid malignancies1,2. The treatment of patients suffering from follicular thyroid carcinoma includes surgery and radioiodine therapy3. Although after definitive therapy, the survival of these patients is good, these patients need to be followed for local recurrences an...

This study retrospectively reviews 60 cases of primary hyperparathyroidism, 21 of whom underwent technetium 99 sestamibi scanning and 10 of whom underwent thallium 201/technetium 99 pertechnetate scanning preoperatively. The sestamibi and thallium scans demonstrated an 89.5% and a 62.5% sensitivity rate for adenoma, respectively. Neither scan demonstrated hyperplastic glands well. Although the ...

Durante S, et al. BMJ Case Rep 2017. doi:10.1136/bcr-2017-222258 Description Tc-sestamibi has been used to evaluate metabolic muscle abnormalities since 25 years. Uptake and retention in myocytes correlates with mitochondrial content and has been used to evaluate muscle functionality and viability. A 2-year-old boy presented with extensive musculoskeletal necrosis due to streptococcal septicaem...

A 34-year-old man with hypercalcemia had a sestamibi scan that showed increased uptake that appeared to correspond with a 7 mm density in the mediastinum, adjacent to the aortic arch, on chest CT. This lesion was thought to be consistent with an ectopic parathyroid adenoma. Prior to surgical exploration, the patient was injected intravenously with 12.3 millicuries of Tc99m-sestamibi. The lesion...

The hypercalcemia of hyperparathyroidism (HPT) can cause devastating effects to the patient and only surgical removal of the hyperfunctioning parathyroid tissue can definitely cure the disease. Radionuclide parathyroid imaging has no role in the diagnosis of hyperparathyroidism or in the selection of the type of treatment. However, once surgery is decided (99m)Tc-sestamibi scanning can localize...

Tc-99m sestamibi has been reported to accumulate in several tissues with increased metabolism and particularly in solid tumors. Although the clinical utility of this radiopharmaceutical has been described in primary breast cancer and its axillary involvement, it has not been fully evaluated in local recurrence or distant metastasis. We illustrate the case of a post-mastectomy patient in whom Tc...

Parathyroid scintigraphies have been used to detect pathological parathyroid glands either before as well as after the parathyroid resection surgery in patients with hyperparathyroidism. One of the most utilized techniques to perform the studies is the double-phase images with Tc-99m sestamibi, which has been shown to be very accurate in the localization of enlarged parathyroid glands. Similar ...

Myocardial perfusion scintigraphy with technetium99m-Sestamibi (99mTc-sestamibi) allows early detection and evaluation of disease extension and cardiovascular risk in patients with suspected or established CAD, helping in decision-making regarding the start and type of therapy to be implemented.1 This method has been widely used, but shows difficulties in some situations such as balanced multiv...

BACKGROUND Intraoperative identification of parathyroid adenomas can be challenging. We hypothesized that low-doses methylene blue (MB) and near-infrared fluorescence (NIRF) imaging could be used to identify parathyroid adenomas intraoperatively. METHODS MB was injected intravenously after exploration at a dose of 0.5 mg/kg into 12 patients who underwent parathyroid surgery. NIRF imaging was ...

Primary hyperparathyroidism is characterized by increased synthesis and release of parathyroid hormone, which produces an elevated serum calcium level and a decline in serum inorganic phosphates. Asymptomatic patients are frequently diagnosed due to screening by automatic multi-chemistry panels. The vast majority of cases of primary hyperparathyroidism (80–85%) are due to single or multiple hyp...