Background: Artemisia diffusa contains a new type of sesquiterpene lactone with an endoperoxide group (Tehranolide). Objective: Due to the existing similarity between the structures of Tehranolide and Artemisinin, it was hypothesized that Tehranolide would have similar effects as Artemisinin. In this study, the immunotherapeutic effec-tiveness of Tehranolide was investigated by direct intra-tum...

Sesquiterpene lactones constitute a large and diverse group of biologically active plant chemical that have been identified in the several plant families.The pharmacological properties of interest involving the sesquiterpene lactones are their antibacterial, antifungal and anti-plusmodial activities.Indeed, assessing the biological activities of the sesquiterpene lactones found in plants and th...

ABSTRACTThe genus Jurinea (Compositae) was reviewed for its chemical constituents and biological significance including traditional uses. The genus has been known for its numerous biological activities like antioxidant, antimicrobial, anticholinesterase, antilipid peroxidation, anti-toxic, antileishmanial activity. Most of the plants of this genus are rich sources of sesquiterpene lactones and ...

The biotransformation of dihydro-epi-deoxyarteannuin B (compound 1) was investigated by using suspension-cultured cells of Averrhoa carambola. One novel sesquiterpene, 7α-hydroxy-dihydro-epideoxyarteannuin B (compound 2, 29.02%), and one known sesquiterpene, 3-α-hydroxy-dihydro-epideoxyarteannuin B (compound 3, 23.26%), were obtained upon the addition of the substrate (compound 1). All the biot...

Rare merosesquiterpenoids, craterellins A-C (1-3), were isolated from cultures of basidiomycete Craterellus odoratus together with the previously known massarinolin C (4). Structures of 1-3 were elucidated on the basis of extensive spectroscopic analysis. Compounds 1-3 possess a rare, epoxymethylenecyclohexanetriol-bicyclofarnesane sesquiterpene hybrid skeleton. Compounds 1-4 were evaluated for...

The purpose of this review, based on studies from our laboratory as well as from others, is to summarize salient features of mast cell immunobiology and to describe their associations with gastrointestinal mucosal defense. Gastrointestinal mast cells are involved in many pathologic effects, such as food hypersensitivity. On the other hand, they also play a protective role in defense against par...

The emergence of the COVID-19 pandemic declared huge need humanity for new and effective antiviral drugs. reported antimicrobial activities Artemisia sublessingiana encouraged us to investigate ethanol extract its aerial parts which led isolation six flavonoids a sesquiterpenoid. structures isolated compounds were elucidated by EI-MS, 1D, 2D NMR spectroscopic methods be (1) eupatilin, (2) 3?,4?...