Background Diabetes nephropathy is a microvascular complication associated with high morbidity and mortality in patients with type 1 diabetes, and its pathogenesis is not fully understood. Our aim was to evaluate the association between levels of serum uric acid and renal function assessed by glomerular filtration rate (GFR) and albuminuria in patients with type 1 diabetes. Methods This is a ...

BACKGROUND There are inconsistent findings on the role of hyperuricemia as an independent risk factor for chronic kidney disease (CKD). Hypertension has been implicated as a factor influencing the association between serum uric acid and CKD. In this population-based study we investigated the association between serum uric acid and decline in renal function and tested whether hypertension modera...

OBJECTIVE Current evidence suggests high serum uric acid may increase the risk of type 2 diabetes, but the association is still uncertain. The aim of the study was to evaluate the association between serum uric acid and future risk of type 2 diabetes by conducting a meta-analysis of prospective cohort studies. DESIGN AND METHODS We conducted a systematic literature search of the PubMed databa...

Aim: To analyze serum uric acid, urea, and creatinine levels in Oral Submucous Fibrosis patients and compare them with those of healthy controls. Materials and Methods: 40 OSMF patients and 20 controls had serum uric acid, urea and creatinine levels measured using spectrophotometer. The data obtained was analyzed using the Statistical Package for the Social Sciences, version 19.0 (SPSS 19). Sta...

Large doses of KCI lowered serum uric acid while producing mild, apparently unrelated, uricosuria in four chlorothiazide-treated subjects. In two control subjects KCI also caused mild uricosuria, but had a negligible effect on serum uric acid concentration. Ammonium chloride decreased serum urate in all six subjects, while urinary uric acid excretion remained essentially unchanged. It is sugges...

PURPOSE Data about the association between serum uric acid and metabolic syndrome in healthy adolescents are sparse. This study examined this association and determined the optimal cutoffs for serum uric acid to predict metabolic syndrome among healthy adolescents. METHODS During 2010-2011, we conducted a cross-sectional study of 927 adolescents (53.0% boys) aged 11-16 years from junior and s...

One proposed mechanism by which alum enhances an immune response is by its ability to induce an inflammatory response that results in the release of uric acid from necrotic cells. Uric acid is thought to be a mediator in enhancing the immune response. The aim of this study was to investigate the immunopotentiating effect of uric acid. Groups of BALB/c mice were injected intraperitoneally with o...

We examined the hypothesis that low levels of serum uric acid are associated with elevated cancer risk. A subpopulation (163,830 members) of a large health maintenance organization was followed for a mean of 9.8 years after a multiphasic health checkup at which serum uric acid level was measured. Total cancer incidence as well as site-specific incidence (for lung, colon, and prostate cancer in ...

In the early studies on atromid, which is ethyl p-chlorophenoxyisobutyric acid (clofibrate or C.P.I.B.) with androsterone, Thorp (1962) reported that, in monkeys, this preparation increased uric acid excretion in addition to lowering plasma lipids. Also Oliver (1962) reported that atromid lowered serum uric acid levels in patients with ischaemic heart disease. We therefore investigated its poss...