Troponin I is a subunit of the thin filament-associated troponin-tropomyosin complex involved in calcium regulation of skeletal and cardiac muscle contraction. We deleted the cardiac isoform of troponin I by using gene targeting in murine embryonic stem cells to determine the developmental and physiological effects of the absence of this regulatory protein. Mice lacking cardiac troponin I were ...

Background: Although it is well known that dyslipidemia is the major risk factor for developing acute coronary syndrome (ACS) but its role in causing minor myocardial damage in unstable angina (UA) patients is rarely studied in south India, where obesity and dyslipidemia has been more common due to genetic and life style factors. Objective: The aim of our study was to find out the role of lipid...

Abstract Background Takotsubo syndrome (TS) and ST-elevation myocardial infarction (STEMI) are both characterized by sudden cessation of contractions (myocardial stunning) as well elevation cardiac troponins B-type natriuretic peptides (BNP). Whereas STEMI results in variable degrees necrosis persistent dysfunction, TS little to any full recovery function. No “head-to-head” comparison the tempo...

Nuclear factor of activated T cell (NFAT) is a ubiquitous regulator involved in multiple biological processes. Here, we demonstrate that NFAT is temporally required in the developing atrial myocardium between embryonic day 14 and P0 (birth). Inhibition of NFAT activity by conditional expression of dominant-negative NFAT causes thinning of the atrial myocardium. The thin myocardium exhibits seve...

Cardiac troponin T alterations in myocardium and serum of rats after stressful, prolonged intense exercise. post-race antimyosin myocardial scintigraphy in asymptomatic marathon runners with elevated serum creatine kinase MB isoenzyme and troponin T levels. Plasma levels of cardiac troponin I after prolonged strenuous endurance exercise. Comparison of serum cardiac specific troponin-I with crea...

Background: Early diagnosis and proper treatment of patient with acute coronary syndrome (ACS) and ischemic heart disease are important in determining prognosis, preventing adverse effects, and may even save lives. In this study, the level of pregnancy-associated plasma protein-A (PAPP-A) in ACS patients was compared with the control group, in addition to cardiac Troponin (cTn) and creatine kin...

Troponin I is the actomyosin ATPase inhibitory subunit present in the thin filament regulatory complex. The complete amino acid sequence of crayfish tail muscle troponin I has been determined. The protein is composed of 201 amino acid residues and has a molecular weight of 23,547. The N terminus is blocked, likely by an acetyl group. Crayfish troponin I shows a rather low (20-25%) sequence iden...

BACKGROUND Diagnostic strategies with ECG and serum cardiac markers have been used to rule out acute myocardial infarction in 6 to 12 hours. The present study evaluated whether a multimarker strategy that used point-of-care measurement of myoglobin, creatine kinase (CK)-MB, and troponin I could exclude acute myocardial infarction in </=3 hours. METHODS AND RESULTS We prospectively enrolled co...

3. Katus HA, Looser S, Hallermayer K, Remppis A, Scheffold T, Borgya A, et al. Development and in vitro characterization of a new immunoassay of cardiac troponin I. Clin Chem 1992;38:386-93. 4. Muller-Bardorif M, Muller G, Hallermayer K, Simon M, Borgya A, Schroder A, et al. Development and characterisation of a specific immunoassay for cardiac troponm T [Abstract]. Eur J Cardiol 1994; 15(Suppl...

BACKGROUND Serum troponin elevation, characteristic of ischemic myocardial injury, has been observed in some acute ischemic stroke (AIS) patients. Its cause and significance are still controversial. The purpose of this study is to find determinants of troponin elevation and its relationship with stroke severity and location. METHODS Between January 2013 and August 2013, 114 consecutive AIS pa...