BACKGROUND Different races have their own reference ranges of serum prostate-specific antigen (PSA) because of the influence of geographical and ethnic differences. In this study we determined the distribution of serum PSA levels in Iraqi men with no prostate cancer, to our knowledge the first such study from Iraq. SUBJECTS AND METHODS From January 2003 to May 2004, in a prospectively designe...

The aim of this study is to compare the role of prostate specific antigen [PSA], digital rectal examination [DRE] and Trans rectal Ultrasonography [TRUS] in detection of prostate cancer among patients presenting with lower urinary tract symptoms [LUTS] and having International Prostate Symptoms Score [IPSS] not less than 7. This study was carried out in I.P.G.M.E.R and S.S.K.M Hospital, Kolkata...

This prospective study investigated the value of serum total prostate specific antigen (tPSA)-based parameters in the diagnosis of prostate cancer (PCa). Serum tPSA, free to tPSA ratio (f/tPSA), PSA density (PSAD), and PSA transition zone (PSAT) were evaluated in 110 patients with histologically confirmed benign prostate hyperplasia (BPH) and 98 patients with PCa. Once the serum tPSA was elevat...

The detrimental effect of chronic chromium (Cr) exposure on the prostate has never been studied. Here, we report the prostate specific antigen (PSA) changes in occupational chromate exposed workers. In this study, eighty six male occupational chromate exposed workers and forty five age-matched controls were recruited. The concentration of Cr in urine (U-Cr), serum total PSA (tPSA), free PSA (fP...

This study investigated the changes of prostate specific antigen (PSA) concentrations in serum and saliva of women during the menstrual cycle. Thirty healthy volunteers (age 23-35 yr) were enrolled in the study. During the menstrual cycle, serum and saliva PSA concentrations on days 9 (follicular phase) and 14 (mid-cycle) were significantly higher than on days 4 (early follicular phase) and 21 ...

OBJECTIVES Preoperative low serum testosterone (TS) level has been reported to be associated with adverse pathologic results in patients with clinically localized prostate cancer (pCA) treated with radical prostatectomy (RP). However, prior studies failed to show prognostic impact of preoperative low TS in these patients. The aim of this study was to investigate the relationship between preoper...

OBJECTIVE To determine matrix metalloproteinase-1 (MMP-1) and tissue-inhibitor metalloproteinase-1 (TIMP-1) serum levels in patients with psoriatic arthritis (PsA) and to compare this with their siblings and local blood donor controls. PsA is an interesting condition in which to study metalloproteinases because there are variations in the level of destructiveness, including a significant propor...

PURPOSE Our aim was to determine a more predictive cut-off value for free to total prostate-specific antigen ratio (f/tPSA) to better differentiate prostate cancer (PCa) from benign prostate hyperplasia (BPH) in Iranian patients with serum PSA levels between 4 and 20 ng/mL. MATERIALS AND METHODS This study was performed on 332 men with serum tPSA level of 4 to 20 ng/mL. All patients underwent...

BACKGROUND Recent evidence suggests that genetic variation in the promoter of the prostate-specific antigen (PSA) gene may contribute to individual variation in serum PSA levels. However, polymorphisms associated with variations in PSA levels have not been identified. METHODS We used the polymerase chain reaction to amplify the promoter region of the PSA genes (nucleotide positions -3873 to -...