The intensity of scattered light varies with the size of the scattering particles. Studying the quantitative immunonephelometric determination of apolipoprotein A-1 (apo A-1), we observed that the different particle sizes of lipoproteins must be taken into account in immunonephelometry if apo A-1 is a constituent of the lipoprotein particles. Because interaction between large lipoproteins and i...

Here, we presented new original data on the effects of iron depletion on the circulating lipid profile in B6HCV mice, a murine model of HCV-related dyslipidemia. Male adult B6HCV mice were subjected to non-invasive iron depletion by low iron diet. Serum iron concentration was assessed for evaluating the effects of the dietary iron depletion. Concentrations of circulating triglycerides, total ch...

In view of the importance now attached to them it is remarkable that the lipoproteins of human serum received so little attention from early workers. In 1929 Machboeuf isolated an alpha-lipoprotein from horse serum and in 1935 McFarlane, in the course of ultracentrifuge studies of human serum, discovered the " X-Fraction " which was later shown by Pedersen to be beta-lipoprotein. The developmen...

There is at present a great deal of interest in factors determining the levels of serum lipids because of their possible relation to atherosclerosis. Since the serum lipids circulate only in the form of lipid-protein complexes, the mechanism of production of these complexes and their delivery into and removal from the serum must be understood before there is a sound basis for defining the homeo...

Lipoprotein lipase activity in lipomatous tissue, post-heparin lipoprotein lipase activity in plasma, and the composition and concentration of serum lipoproteins were studied in 15 patients with Multiple Symmetric Lipomatosis (MSL). Extremely elevated lipoprotein lipase activity in adipose tissue was found in MSL patients. Total and hepatic post-heparin plasma lipolytic activity was normal, whi...

Cardiovascular diseases with an incidence of approximately 50% are the main causes of death in most advanced countries and an increasing trend in the developing world as well. The World Health Organization estimates that 12 million people per year worldwide die from cardiovascular diseases. Cardiovascular diseases are becoming an increasing problem worldwide and hypercholesterolemia has been co...