Glycogenic hepatopathy (GH) is a rare complication of type 1 diabetes mellitus. We report the case of a 13-year-old diabetic female with poorly controlled blood sugar levels who presented with abdominal pain and distention 1 month in duration. She exhibited tender hepatomegaly, an elevated lipid profile, and elevated serum transaminase levels. Her liver histology was consistent with GH. The pat...

OBJECTIVE We wished to study alterations in serum insulin-like growth factor-I (IGF-I) and its binding proteins in subjects with insulin dependent diabetes mellitus (IDDM) and possible relations with metabolic and GH secretory status, before and after cholinergic modulation. In addition, we have investigated whether cholinergic modulation exerts any effects on IGF-I secretion, independently of ...

OBJECTIVE Adult survivors of childhood acute lymphoblastic leukaemia (ALL) often exhibit GH deficiency (GHD), due to prophylactic cranial radiotherapy (CRT). It is not known whether the observed risk for adiposity in these patients is associated with impaired insulin sensitivity and whether the insulin sensitivity is affected by GH replacement therapy. SUBJECTS AND DESIGN Eleven patients with...

The purpose of this study was to measure serum levels insulin-like growth factor-binding protein (IGFBP7), Insulin-like Growth Factor 1 (IGF-1), Hormone (GH), Interleukin 6 (IL-6) and insulin in acromegaly patients healthy controls. group had 60 patients, while the population 30 people who never before. concentration IGFBP7, IGF-1, GH, IL-6, were determined. results present indicate that IGFBP7...

Gigantism indicates excessive secretion of growth hormones (GH) during childhood when open epiphyseal growth plates allow for excessive linear growth. Case one involved a 14.7-year-old boy presented with extreme tall stature. His random serum GH level was 38.4 ng/mL, and failure of GH suppression was noted during an oral glucose tolerance test (OGTT; nadir serum GH, 22.7 ng/mL). Magnetic resona...

Both thyroid hormone and hypothalamic growth hormone (GH)-releasing factor (GRF) facilitate pituitary somatotroph function. However, the pathophysiological role of thyroid hormone in GRF secretion is less well understood. Thyrotoxicosis, induced by administration of thyroxine (T4) in rats, inhibited both pituitary GH levels and immunoreactive GRF secretion from incubated hypothalamus. At the hi...

OBJECTIVE Growth hormone secretion is decreased in obese subjects, and their GH response to stimulation tests is blunted. The mechanisms relating excess adipose mass and GH secretion are unknown. We hypothesized that leptin might be a signal linking adipose mass to GH secretion. DESIGN We measured serum leptin levels and the GH response to stimulation tests in 42 obese and 40 lean short norma...

methyldopa given for two to six weeks causes a rise in serum prolactin concentrations in hypertensive patients. Our studies have confirmed that patients on long-term treatment with methyldopa have raised serum prolactin concentrations. Furthermore, we have shown that even a single oral dose of methyldopa will increase serum prolactin concentrations. Basal serum prolactin levels varied considera...

introduction: adenotonsillar hypertrophy (ath) may present with growth retardation. insulin-like growth factor 1 (igf-1) mediates the anabolic effects of growth hormone (gh) on tissues. most of the circulating igf-1 molecules are bound to insulin-like growth factor-binding protein 3 (igfbp-3). igf-1 and igfbp-3 serum levels reflect the levels of daily mean serum gh and are used as indices for e...

Shah, N., W. S. Evans, and J. D. Veldhuis. Actions of estrogen on pulsatile, nyctohemeral, and entropic modes of growth hormone secretion. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R1351–R1358, 1999.—The neuroendocrine mechanisms by which estradiol drives growth hormone (GH) secretion in the human are poorly defined. Here we investigate estrogen’s specific regulation of th...