The development of a specific, sensitive homologous ovine follicle stimulating hormone (FSH) radioimmunoassay (RIA) is described. The key procedural modifications of basic RIA methods were immunoabsorpt ion of the anti-ovine FSH serum with lutenizing hormone (LH) to improve specificity and adsorption chromatography of the radioiodinated ovine FSH on hydroxyapat i te (HTP) to improve immunoreact...

Follicle-Stimulating Hormone Receptor (FSHR) -29G/A polymorphism (rs1394205) was reported to modulate gene expression and reproductive parameters in women, but data in men is limited. We aimed to bring evidence to the effect of FSHR -29G/A variants in men. In Baltic young male cohort (n = 982; Estonians, Latvians, Lithuanians; aged 20.2 ± 2.0 years), the FSHR -29 A-allele was significantly asso...

Purpose: To evaluate the effects of leuprorelin plus growth hormone on serum luteinizing (LH), follicle-stimulating (FSH), and estradiol (E2) levels in children with idiopathic central precocious puberty. Methods: A total 102 girls puberty who met inclusion criteria between April 2020 September 2021 were enrolled this study, assigned randomly to either a control group given only, or combined tr...

Background: An important global health issue, infertility affects a couple’s social, psychological, economic, and sexual well-being. A variety of issues stemming from abnormal hypothalamus pituitary ovarian axis dysfunction make up the hormonal diseases female reproductive system. The aim study was to find correlation between prolactin, thyroid, LH, FSH, estradiol progesterone in infertile wome...

BACKGROUND Schizophrenia is a prevalent neurodevelopmental disorder of an unknown etiology and a variable phenotypic expression. In the recent years, the impact of hormones on the course of schizophrenia has been investigated. This study is aimed at assessing the level of correlating serum levels of hormones in schizophrenic male patients with their cognitive functioning measured with neuropsyc...

Precocious Puberty in a 2-year-old boy  A 2-year-old boy with precocious isosexual matura- (3) Lion is reported.  The pubertal values of serum LH, FSH and Testoste- (4) on and lack of any other pathologic finding were in favour of diagnosis of idiopathic sexual precocity.  The L.R.F. response test was of the adult pattern. The serum LH, FSH and Testosterone decreased following (5) treatment ...

The gonadotropin-ovary axis of patients with anorexia nervosa was assessed with the aim of distinguishing between an intrinsically hypophysial deficiency and pituitary malfunction secondary to hypothalamic impairment. The most consistent endocrine abnormality was low serum luteinizing and follicle stimulating hormone (LH and FSH) levels associated with depressed serum estradiol levels. Gonadotr...

We identified a new point mutation in the CYP19 gene responsible for aromatase (P450arom) deficiency in a 46,XY male infant with unremarkable clinical findings at birth. This boy is homozygote for a 1-bp (C) deletion in exon 5 of the aromatase gene causing a frame-shift mutation. The frame-shift results in a prematurely terminated protein that is inactive due to the absence of the functional re...

BACKGROUND The number of terminal sialic acid and sulfonated N-acetylgalactosamine (SO(3)-GalNAc) on gonadotrophins in serum varies during the menstrual cycle and changes at menopause, suggesting that gonadal steroids modify their oligosaccharide synthesis. Our objective was to determine the effects of 17beta-oestradiol (E(2)) and a progestogen, norethisterone acetate (NETA), on the sulfonation...

The effect of anti-follicular stimulating hormone (FSH) on testicular lipid and the specific activity of testicular enzymes of the isocitrate dehydrogenase (ICDH), pyruvate/malate dehydrogenase (MDH) and malic enzyme involved in lipogenesis were studied in mature bonnet monkeys, Macaca radiata. Immunization of monkey with anti-FSH for 24 days did not produce any significant changes in the body ...