Sir, We read with great interest the recently published article by Broeders et al. with regard to the ®brate-induced increase in blood urea and creatinine w1x. Taking into account these ®ndings, we retrospectively reviewed the charts of patients treated with ®brates, in the lipid clinic of our university hospital. In the study we included patients without any evidence of renal dysfunction, not ...

Amin A. Nanji, Division of Clinical Chemistry, Vancouver General Hospital, Vancouver V5Z1M9 (Canada) Dear Sir, Analytical and biologic variations in serum and urinary creatinine may account for up to 33% variability in creatinine clearance calculations [1]. We wish to report on the marked variability of creatinine clearance in patients receiving total parenteral nutrition (TPN). 18 of 93 patien...

Biomarkers have been used to screen for kidney disease since creatinine was recognized to be correlated with renal function. The measurement of serum creatinine as a screening test for kidney disease falls short, however, because serum creatinine is not particularly sensitive for the diagnosis of kidney disease. Creatinine reflects renal filtering capacity, which has a lot of reserve and is the...

background: acute kidney injury (aki) is a common problem in critically ill patients and is independently associated with increased morbidity and mortality. recently, serum cystatin c has been shown to be superior to creatinine in early detection of renal function impairment. we compared estimated gfr based on serum cystatin c with estimated gfr based on serum creatinine for early detection of ...

A method for the determination of creatinine in human serum by isotope dilution-mass spectrometry is described. The analytical procedure comprises the following steps: Addition of [13C,15N2 )creatinine to the serum sample; ion exchange chromatography on the cation exchange resin AG 50W-X2; formation of the trimethylsilyl derivative; gas liquid chromatography-mass spectrometry (GC-MS); selected ...

BACKGROUND We have known that patients with renal insufficiency (creatinine level) have increased mortality for coronary artery disease. In this study, the relationship between admission creatinine level and one year mortality are evaluated in patients with acute myocardial infarction (AMI). METHOD 160 AMI patients (127 men and 33 women with a mean age of 59 ± 13) were enrolled in the study. ...

BACKGROUND Serum cystatin C, a cysteine protease inhibitor, has been suggested as a new marker of glomerular filtration rate (GFR). This study explored the possibility of replacing the creatinine clearance (CrCl) estimation of GFR with cystatin C in early detection of renal impairment in cancer patients on chemotherapy. METHODS Serum creatinine and cystatin C concentrations as well as 24-h Cr...

OBJECTIVE To determine the impact of preoperative serum creatinine level in non-dialyzable patients on postoperative morbidity and mortality. METHODS This is a prospective study, where serum creatinine was used to give primary assessment on renal function status preoperatively. This study includes 1,033 patients, who underwent coronary artery bypass grafting, or valve(s) operations. The study...

BACKGROUND Statins are shown effective by some studies in preventing contrast-induced nephropathy (CIN). We evaluated the effectiveness of atorvastatin in the prevention of CIN in computed tomography angiography (CTA) candidates. METHODS This study was conducted on patients referring for elective CTA with normal renal function. Patients received atorvastatin (80 mg/day) or placebo from 24 h b...