OBJECTIVE To study the relation of smoking and abnormal renal function in type 2 diabetes mellitus by estimating urine protein- creatinine ratio, blood urea, serum creatinine, glomerular filtration rate and serum lipid profile in selected subjects. METHODS Diabetic patients who attended the Diabetic Clinic, Medical College, Kozhikode were enrolled in the study. The study duration was 6 months...

In the present study, we investigated the effects of the aqueous extract of Mucuna pruriens against gentamicin (100 mg kg -1 per day for six days) induced oxidative stress and nephrotoxicity in rats. Administration of gentamicin to rats induced a marked renal failure, characterized by a significant increase in urine volume and serum creatinine and urea levels. There was a significant decr...

A 4-year-old Caucasian girl was admitted with a 4-day history of fever, diarrhea and vomiting, and 12-hs of oliguria. Her past medical history was negative for any renal disease. On admission, she had a temperature of 39.5oC and blood pressure of 93/48 mm Hg. Physical examination was normal. Investigations showed leukocytosis with 88% neutrophils and anemia (hemoglobin level of 8.7 g/ dL), elev...

Aim: Study was undertaken to evaluate the effect of Punica granatum L. on Gentamicin-induced renal failure in rats. Materials and methods: Gr. I rats served as normal, received 0.5 ml of 5% Tween-80 in distilled water, Gr. II was injected with Gentamicin (100 mg/kg, IP), Gr. III was injected with Gentamicin and selenium (2 mg/kg, IP), and Gr. IV-IX were given orally Punica granatum fruit chloro...

The importance of Tinospora cordifolia stem extract was investigated for its possible curative effect in male wistar rats against the cisplatin induced nephrotoxicity. Oral administration of plant extract cured the cisplatin induced kidney damage. There was an increase in serum creatinine, blood urea nitrogen and alkaline phosphatase in rats treated with Cisplatin (5mg/kg body weight, i.p). Adm...

The aim of the study was to investigate impact lameness on nitrogen (N) metabolism and excretion. Two treatment groups 20 multiparous Holstein–Friesian dairy cows were included in study; control group consisted with locomotion score ≤2, while experimental scores 3 4. Fodder, milk, feces, urine collected determine emissions. milk yield, energy-corrected fat protein yield higher for lame animals ...

Gentamicin nephrotoxicity limit its usage against gram negative bacteria. Most researches showed that antioxidant agents improved gentamicin nephrotoxicity. According to these investigations oxidative stress play a central role in the mechanism of gentamicin induced nephrotoxicity. Recently Rafieian-Kopaei and colleagues showed that erythropoietin significantly ameliorated serum creatinine, blo...

Submit Manuscript | http://medcraveonline.com MOJ Toxicol (2016), 2(1): 00026 Abbreviations: RPM: Revolutions Per Minute; AST: Serum Aspartate Aminotransferase; ALT: Serum Glutamate Pyruvate Transaminase; Scr: Serum Creatinine; BUN: Blood Urea Nitrogen; C: Control; V: Venom; VC : Vitamin; VVC: Venom+Vitamin C ; TBS :Tris Buffered Saline; SOD: Superoxide Dismutase; Cat: Catalase; GSH-Px: Glutath...

    Background & Objective:  Acetaminophen is known as the most common agent which causes hepatic and renal toxicity in human and experimental animals at supra-therapeutic doses. The current study investigated the protective effects of Descurainia sophia seed extract on the acetaminophen-induced nephrotoxicity markers in male mice.  Materials & Methods:  Experimental male mice (n=60, Swiss alb...