نتایج جستجو برای: sertoli cell condition medium

تعداد نتایج: 2157061  

2011
Enrico Bigliardi Pietro Parma Paolo Peressotti Lisa De Lorenzi Peter Wohlsein Benedetta Passeri Stefano Jottini Anna Maria Cantoni

Male pseudohermaphroditism is a sex differentiation disorder in which the gonads are testes and the genital ducts are incompletely masculinized. An 8 years old dog with normal male karyotype was referred for examination of external genitalia abnormalities. Adjacent to the vulva subcutaneous undescended testes were observed. The histology of the gonads revealed a Leydig and Sertoli cell neoplasi...

Journal: :Reproduction, nutrition, development 2002
Larry Johnson Christophe Staub Robert L Silge Martha W Harris Robert E Chapin

Perinatal and juvenile oral treatment of rats with the insecticide, methoxychlor (MXC), reduced testicular size and other reproductive indices including the number of epididymal spermatozoa in those animals as adults 161. The objective was to determine if these males exposed during development had fewer Sertoli cells which might explain these testicular effects. Rat dams were gavaged with MXC a...

Journal: :Journal of andrology 2000
J P Wiebe A Kowalik R L Gallardi O Egeler B H Clubb

Intratesticular injections of glycerol have been shown to result in a marked and prolonged reduction of spermatogenesis, accompanied by increased permeability of the blood-testis barrier. Because the permeability of the blood-testis barrier is regulated by Sertoli cell tight junctions, and tight junction organization is regulated by the cytoskeleton, we undertook to examine the effects of glyce...

Journal: :Journal of medical genetics 2011
Ingrid Slade Chiara Bacchelli Helen Davies Anne Murray Fatemeh Abbaszadeh Sandra Hanks Rita Barfoot Amos Burke Julia Chisholm Martin Hewitt Helen Jenkinson Derek King Bruce Morland Barry Pizer Katrina Prescott Anand Saggar Lucy Side Heidi Traunecker Sucheta Vaidya Paul Ward P Andrew Futreal Gordan Vujanic Andrew G Nicholson Neil Sebire Clare Turnbull John R Priest Kathryn Pritchard-Jones Richard Houlston Charles Stiller Michael R Stratton Jenny Douglas Nazneen Rahman

BACKGROUND Constitutional DICER1 mutations were recently reported to cause familial pleuropulmonary blastoma (PPB). AIM To investigate the contribution and phenotypic spectrum of constitutional and somatic DICER1 mutations to cancer. METHODS AND RESULTS The authors sequenced DICER1 in constitutional DNA from 823 unrelated patients with a variety of tumours and in 781 cancer cell lines. Cons...

2014
Helen E Abud Gary R Hime

The dramatic changes that male germ cells in the adult testis undergo in gene expression profile and morphology as they transition from spermatogonial stem cells through to mature spermatozoa is dependent upon their association with Sertoli cells. Sertoli cells are crucial for survival and maturation of male germ cells. Two recent papers, Holembowski et al. and Inoue et al. have described a sur...

2012
Gurvinder Kaur Jannette M. Dufour

Cell lines are often used in place of primary cells to study biological processes. However, care must be taken when interpreting the results as cell lines do not always accurately replicate the primary cells. In this article, we will briefly talk about advantages and disadvantages of cell lines and then discuss results using the mouse Sertoli cell line, MSC-1, compared with primary mouse Sertol...

2012
Otávio Brilhante Fatima K Okada Estela Sasso-Cerri Taiza Stumpp Sandra M Miraglia

BACKGROUND Doxorubicin is a potent chemotherapeutic drug used against a variety of cancers. It acts through interaction with polymerases and topoisomerase II and free radical production. Doxorubicin activity is not specific to cancer cells and can also damage healthy cells, especially those undergoing rapid proliferation, such as spermatogonia. In previous studies our group showed that etoposid...

Journal: :American journal of physiology. Endocrinology and metabolism 2009
Charles M Allan Patrick Lim Mathew Robson Jenny Spaliviero David J Handelsman

We have characterized the in vivo actions of human wild-type FSH receptor (FSHR) overexpressed in Sertoli cells of transgenic (Tg) mice (TgFSHRwt) compared with transgenic overexpression of the human activated mutant FSHR*D567G (TgFSHR*D567G). Testicular TgFSHRwt expression significantly elevated specific FSH binding (>2-fold, P < 0.01) relative to nontransgenic testes, similar to increased FSH...

Journal: :Mechanisms of Development 2012
Ryo Sugimoto Yo-ichi Nabeshima Shosei Yoshida

Homeostasis of tissues relies on the regulated differentiation of stem cells. In the epithelium of mouse seminiferous tubules, the differentiation process from undifferentiated spermatogonia (A(undiff)), which harbor the stem cell functions, to sperm occurs in a periodical manner, known as the "seminiferous epithelial cycle". To identify the mechanism underlying this periodic differentiation, w...

2013
Elisenda Sanz Ryan Evanoff Albert Quintana Elizabeth Evans Jeremy A. Miller Chemyong Ko Paul S. Amieux Michael D. Griswold G. Stanley McKnight

Male spermatogenesis is a complex biological process that is regulated by hormonal signals from the hypothalamus (GnRH), the pituitary gonadotropins (LH and FSH) and the testis (androgens, inhibin). The two key somatic cell types of the testis, Leydig and Sertoli cells, respond to gonadotropins and androgens and regulate the development and maturation of fertilization competent spermatozoa. Alt...

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