Self-renewal and differentiation of stem cell depend on a dynamic interplay of cell-extrinsic and -intrinsic regulators. However, how stem cells perceive the right amount of signal and at the right time to undergo a precise developmental program remains poorly understood. The cell surface proteins Glypicans act as gatekeepers of environmental signals to modulate their perception by target cells...

We investigate general properties of nondeterministic self-assembly with asymmetric interactions, using a computational model and DNA tile assembly experiments. By contrasting symmetric and asymmetric interactions we show that the latter can lead to self-limiting cluster growth. Furthermore, by adjusting the relative abundance of self-assembly particles in a two-particle mixture, we are able to...

Diversity of today’s architectures have forced programmers and compiler researchers to port their application across many different platforms. Compiler auto-tuning itself plays a major role within that process as it has certain levels of complexities that the standard optimization levels fail to bring the best results due to their average performance output. To address the problem, different op...

From an interplay of high-resolution scanning tunneling microscopy (STM) imaging and density functional theory (DFT) calculations we demonstrate that by delicately choosing the parent molecule (adenine) we are able to tune the self-assembled nanostructures of adenine derivatives which are directed by the specific intermolecular interactions provided by the adenine moiety.

The self-assembly of linear polymers containing chiral IL units generates a high-order supramacromolecular structure with a complex hierarchical architecture, which is able to exhibit thermoresponsive behavior (lower critical solution temperature: LCST) with different structural elements that can be used to fine tune this LCST.

Abstract Spontaneous locking of the phase a coherent phonon source to an external reference is demonstrated in deeply sideband-unresolved optomechanical system. The high-amplitude mechanical oscillations are driven by anharmonic modulation radiation pressure force that result from absorption-mediated free-carrier/temperature limit cycle, i.e., self-pulsing. Synchronization observed when pump la...