Cellular function requires biomolecules to undergo dynamic transitions that include folding, conformational rearrangements, and large-scale assembly. The result is a highly interdependent network of processes that is maintained by a balance of thermodynamic and kinetic factors. In molecular machines, each constituent biopolymer (i.e., a chain of residues) first folds to a lowenergy configuratio...

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BACKGROUND In sea urchins, spermatozoan motility is altered by chemotactic peptides, giving rise to the assumption that mammalian eggs also emit chemotactic agents that guide spermatozoa through the female reproductive tract to the mature oocyte. Mammalian spermatozoa indeed undergo complex adaptations within the female (the process of capacitation) that are initiated by agents ranging from pH ...

One of the factors which limits the transmission capacity of the fiber optics communication channel is the material dispersion. Exact analytical study of the material dispersion is often complex and involves calculating the derivatives of the refractive index of the core. These calculations are too cumbersome to do, especially for high-order derivatives. So material dispersion has only been stu...

By the end of this year visitors to the Flemish town of Mechelen can discover the city with the help of the new CityInMyPocket walking guide. Instead of following a person or a book, people can pick up a CityInMyPocket digital walking guide and go sightseeing at their own speed. So, leave your heavy guidebooks and many flyers at home. CityInMyPocket will tell you just as much, and even more. Ci...

INTRODUCTION Primary care providers have limited time for physical activity counseling. They can optimize counseling time by referring patients to community resources for more comprehensive support. To facilitate referrals, resource guides (lists of community opportunities with descriptive information) are often created but seldom used. We elicited the detailed opinions of providers about how t...