Selenium is a non-metallic chemical element of great important to human health. Low selenium levels in humans are associated with several pathological conditions and are a common finding in HIV infected individuals. We conducted a review of the literature to assess if selenium deficiency or selenium supplementation could play a role in modifying the clinical course of HIV disease. Several studi...

Selenium is known to be present in the bile of selenium-treated animais. Smith et al. (I) reported that rabbit bile, after acute and subacute poisoning with sodium selenite and selenate (0.5 to 3 mg. of selenium per kilo), contained smaller amounts of selenium (36 to 48 y per cent) after oral treatment than after intravenous treatment (336 y per cent). In studies by Dudley (2), it was found, af...

Selenium is essential to human health, and its deficiency is associated with different diseases including liver necrosis. Selenium is protective against viral hepatitis and hepatocellular carcinoma (HCC). The underlying molecular mechanisms of selenium effects are not well known. In this study, in vitro response of HCC-derived cell lines to selenium deficiency is examined alone or in conjunctio...

SOIL ASSOCIATIONS The selenium content of most soils ranges from 0.1 to 2 parts per million. But in general soil selenium content by itself is not a good measure for the potential for occurrence of selenium deficiency in livestock grazing or consuming forages produced from it. Soil pH has a marked effect on the form of selenium present and its availability to the plant. In alkaline, well-aerate...

BACKGROUND Selenium has been shown to inhibit cancer development and growth through the mediation of selenium-binding proteins. Decreased expression of selenium-binding protein 1 has been reported in cancers of the prostate, stomach, colon, and lungs. No information, however, is available concerning the roles of selenium-binding protein 1 in uterine leiomyoma. METHODS Using Western Blot analy...

BACKGROUND The New Zealand population has both marginal selenium status and mild iodine deficiency. Adequate intakes of iodine and selenium are required for optimal thyroid function. OBJECTIVE The aim of the study was to determine whether low selenium and iodine status compromises thyroid function in an older New Zealand population. DESIGN We investigated the effects of selenium and iodine ...

AIMS AND BACKGROUND A direct association between exposure to the metalloid selenium and risk of cutaneous melanoma has been suggested by some observational and experimental cohort studies, whereas other studies have yielded inconsistent results. Since some of the inconsistencies may be due to exposure misclassification arising from the use of exposure indicators that do not adequately reflect b...

due to the fact that a considerable part of europe, including some regions of poland, isconsidered to be deficient in selenium, it seems necessary to develop a selenium map for different regions of poland, which will be used in future to prepare a prophylaxis programme against selenium deficiency inanimals. the aim of the study was to determine selenium content in selected organs (liver and kid...

The bioeffects of selenium on the growth of Spirulina platensis and the selenium distribution were investigated. S. platensis was batch cultured in Zarrouk medium containing increasing concentrations of sodium selenite. The biotransformation characteristic of selenium was analysed by the determination of the detailed selenium distribution forms. At 35 degrees C, 315.2 microEm(-2) x s(-1), sodiu...

OBJECTIVE To investigate the effect of selenium supplementation on the selenium status and selenoenzyme, especially the activity and mRNA expression of type 1 deiodinase (D1) in mice with excessive iodine (EI) intake and to explore the mechanism of selenium intervention on iodine-induced abnormities. METHODS Weanling female BALB/c mice were given tap water or 3 mg/L of iodine or supplemented ...