Detailed safety assessment of sodium selenite and bioselenium (bio-Se) was conducted and the results were compared and discussed for the purpose of assessing safety of bio-Se for use in food applications. In this work, acute toxicity studies, micronucleus test, and sperm aberration study in mice, 30-day feeding test of mice, were conducted to evaluate the toxicity of bio-Se obtained from yeast ...

Effects of Sodium Selenite on Methylmercury Embryotoxicity and Teratogenicity in Mice. NOBUl'AGA, T., SATOH, H., AND SUZUKI, T. (1979). Toxicol. Appl. Pharmacal. 47, 79-88. Female IVCS mice were fed food containing methylmercury (MeHg) at 0, 15.9, or 31.9 nmol g food and drinking water containing sodium selenite at 0, 11.4, or 22.8 nmol·ml for 30 days before gestation and thereafter up to Day 1...

Surface coal mine spoil was studied to evaluate selenium (Se) mobility and solubility using batch experiments, column-Ieachmg techniques, and sequential and individual extraction processes. Both selenite and selenate followed linear isotherm patterns at relatively lower Se treatments, whereas over a broader solution Se concentraton range the sorption mechanism followed the Lanpuir model. The va...

The present investigation was performed to determine the effect of long-term administration of sodium selenite on the biochemical indices and concentration of thyroid hormones in calves. Sodium selenite solution was drenched at 0.1 and 0.25 mg per kg body weight for 12 weeks. Higher dose produced characteristic symptoms of selenosis whereas mild symptoms were observed with lower dose. The toxic...

background: the aim of this study was to evaluate the possible protective effect of sodium selenite on serum, liver, and kidney antioxidant enzymes activities in alloxan-induced type 1 diabetic rats. methods: forty sprague-dawley male rats were randomly divided into four groups; group one as control, group two as sham-treated with sodium selenite by 1 mg/kg intraperitoneal (i.p.) injections dai...

A series of zirconium-based, metal-organic frameworks (MOFs) were tested for their ability to adsorb and remove selenate and selenite anions from aqueous solutions. MOFs were tested for adsorption capacity and uptake time at different concentrations. NU-1000 was shown to have the highest adsorption capacity, and fastest uptake rates for both selenate and selenite, of all zirconium-based MOFs st...

Although supplementation with the selenocompound, sodium selenite has been shown to stimulate the concanavalin A-induced T-cell mitogenic response, the mechanisms responsible remain unclear. This study was conducted to evaluate the relationships between the induction of apoptosis, formation of tumor necrosis factor (TNF)-alpha and reactive oxygen species (ROS), activation of apoptosis signal-re...

A selenium-binding protein (SeBP) from Methanococcus vannielii was recently identified, and its gene was isolated and overexpressed in Escherichia coli [Self, W. T., Pierce, R. & Stadtman, T. C. (2004) IUBMB Life 56, 501-507]. SeBP and recombinant SeBP (rSeBP) migrated as approximately 42-kDa species on native gels and as approximately 33-kDa species on SDS gels. rSeBP consists of identical 8.8...

Objective- This study aimed at evaluation of histopathological findings of application of chitosan- nano selenium biodegradable film on full thickness excisional wound healing in rats. Design- Experimental Study Animals- Seventy-two male Wistar rats Procedures- Animals were randomized into six groups of 12 animals each. Group I: Animals with created wounds and no...

Various mechanisms have been proposed to explain the biological dissimilatory reduction of selenite (SeO3(2-)) to elemental selenium (Se(o)), although none is without controversy. Glutathione, the most abundant thiol in the eukaryotic cells, the cyanobacteria, and the alpha, beta, and gamma groups of the proteobacteria, has long been suspected to be involved in selenium metabolism. Experiments ...