the urgent need of neuraminidase inhibitors (ni) has provided an impetus for understanding the structure requisite at molecular level. our search for selective inhibitors of neuraminidase has led to the identification of pharmacophoric requirements at various positions around acyl thiourea pharmacophore. the main objective of present study is to develop selective ni, with least toxicity and dru...

in this researchsaccharomyces cerevisiae (baker’s yeast) was used as a cheap, readily accessible, selective, efficient, and green bio-catalyst in a chemo selective reduction of carbonyl group to hydroxyl group. in this green procedure three substrates e.g. (3-(3-nitrophenyl)aziridin-2-yl)-1-phenyl-methanone, pyruvate ester, and 2-acetyl-γ-butyrolactone were reduced to their corresponding reduce...

an iodide ion-selective pvc membrane sensor based on copper (π)-bis-nphenilsalicyldenaminatocomplex as a novel sensing material is successfully developed. theelectrode showed a good selectivity for iodide ion with respect to common inorganic anions. thesensor exhibited a good linear response with slope of _58.6 ± 0.4 mv per decade over theconcentration range of 5.0 × 10-6 to 1.0 × 10-1 mol l-1,...

a three-step selective photo-ionization for gd155 and gd157 isotopes by pulsed laser wasevaluated numerically. due to large thermal neutron absorption cross sections, these two isotopes innatural gadolinium are good candidates as burnable poison to control reactivity early in the fuel cycleand allow extended fuel burn up. rate equations have been used to calculate the dynamics of the isotopepop...

aim and background: considering the high frequency of anxiety and depressive symptoms in irritable bowel syndrome (ibs) patients, selective serotonin reuptake inhibitors (ssris) are recommended by some gastroenterologists for treatment. in this study, the efficacy of fluvoxamine on severity of symptoms and quality of life in ibs patients was assessed. methods and materials: a randomized, double...

Selective mutism is typically a symptom of an anxiety disorder, requiring treatment in conjunction with mental health professionals. The full impact of the disorder is not usually manifested until the child starts school, and therefore the classroom is frequently where the difficulties are most seriously experienced. Thus, the teacher is often the focal point of the child’s most intense symptom...

Objective(s):This study was carried out to investigate the effects of COX-2 selective inhibitor (Celecoxib) or non-selective COX inhibitor (Ibuprofen) on gastrointestinal motility. Materials and Methods: The rats were randomly divided into five groups including: intact, sham, traumatic brain injury (TBI) group (intact rats under TBI), Celecoxib group (10 mg/kg), Ibuprofen group (10 mg/kg). Rats...

2,6-diaminopyridine is extensively used as a pharmaceutical intermediate and a hair dye coupler as oxidation formulations. It is soluble in protic solvents. Primary and secondary amines are N-methylated by various methods such as direct alkylation of amines with Hofmann mechanism, but in many of these methods due to overalkylations, we earn a mixture of amino products. Consequently, they aren't...