نتایج جستجو برای: seipin
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BACKGROUND Protein aggregation and the formation of intracellular inclusions are a central feature of many neurodegenerative disorders, but precise knowledge about their pathogenic role is lacking in most instances. Here we have characterized inclusions formed in transgenic mice carrying the P56S mutant form of VAPB that causes various motor neuron syndromes including ALS8. RESULTS Inclusions...
Xin-Gui Peng, Shenghong Ju, Fang Fang, Yu Wang, Ke Fang, Xin Cui, George Liu, Peng Li, Hui Mao, and Gao-Jun Teng Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, China; Bruker BioSpin, Beijing, China; Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, M...
The lipid droplet (also known as lipid particle and oil body) is a dynamic organelle whose boundary is surrounded by a phospholipidmonolayer andwhose inner core is composedmainly of triacylglycerol (TAG) and steryl esters. The monolayer surface is coated with an assortment of proteins that serve structural and metabolic functions. Although the existence of lipid droplets in mammalian cells, pla...
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